Aldehyde Dehydrogenase Antikörper (AA 7-128)

Produktnummer ABIN968411

Produktdetails anti-Aldehyde Dehydrogenase Antikörper

Target: Aldehyde Dehydrogenase (ALDH)

Bindungsspezifität: AA 7-128

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Aldehyde Dehydrogenase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Please refer to us for technical protocols.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human ALDH1 aa. 7-128

Klon: 44-ALDH

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389, ABIN968533

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-Aldehyde Dehydrogenase Antikörper (ABIN968411)

Zhou, Hanna, Roberts, Weber, Bell: "ALDH1 immunohistochemical expression and its significance in salivary adenoid cystic carcinoma." in: Head & neck, Vol. 35, Issue 4, pp. 575-8, (2013) (PubMed).

Greene, Bahn, Masson, Rabbitts: "The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development." in: Molecular and cellular biology, Vol. 18, Issue 12, pp. 7030-7, (1998) (PubMed).

Yoshida, Rzhetsky, Hsu, Chang: "Human aldehyde dehydrogenase gene family." in: European journal of biochemistry / FEBS, Vol. 251, Issue 3, pp. 549-57, (1998) (PubMed).

Kathmann, Lipsky: "Cloning of a cDNA encoding a constitutively expressed rat liver cytosolic aldehyde dehydrogenase." in: Biochemical and biophysical research communications, Vol. 236, Issue 2, pp. 527-31, (1997) (PubMed).

Details zu Aldehyde Dehydrogenase

Target: Aldehyde Dehydrogenase (ALDH)

Andere Bezeichnung: ALDH (ALDH Produkte)

Synonyme: 146084_at antikoerper, ACDH antikoerper, ALDH antikoerper, CG 3752 antikoerper, CG3752 antikoerper, Dmel\\CG3752 antikoerper, GB12741 antikoerper, Tb06.26G9.1140 antikoerper, Aldehyde dehydrogenase antikoerper, ALdehyde deHydrogenase antikoerper, aldehyde dehydrogenase, mitochondrial antikoerper, aldehyde dehydrogenase antikoerper, betaine-aldehyde dehydrogenase antikoerper, ran-specific GTPase-activating protein antikoerper, Aldh antikoerper, alh-6 antikoerper, alh-12 antikoerper, LOC550687 antikoerper, aldH antikoerper, Tb927.6.4210 antikoerper, HQ_RS05000 antikoerper, aldA-2 antikoerper, ALDH antikoerper, LOC618976 antikoerper

Hintergrund: Aldehyde dehydrogenase (ALDH) is a ubiquitous enzyme located in nearly all mammalian tissues. It catalyzes the irreversible oxidation of a range of aliphatic and aromatic aldehydes to their corresponding carboxylic acids. There are multiple isoforms of ALDH which are subdivided into three classes. Class I includes the cytosolic isoforms. Class II includes the mitochondrial isoforms. Class III includes the microsomal, cytosolic tumor specific, and cytosolic dioxin-inducible forms. At least twelve human ALDH isoforms have been identified. Mutations of many of these proteins such as ALDH1, ALDH2, ALDH4, and ALDH10 have been implicated in multiple human metabolic disorders and clinical abnormalities. At the amino acid level, human ALDH isoforms exhibit a wide range of diversity (15% to about 80%). However, multiple protein regions have been highly conserved and are important for functional activities. A well-characterized member of the human ALDH family is ALDH1. It plays a major role in the biosynthesis of retinoic acid from retinol (vitamin A). Retinoic acid, the biologically active form of retinol, is a regulator of cellular proliferation, differentiation, and survival.

Molekulargewicht: 55 kDa