Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

Aldehyde Dehydrogenase Antikörper (AA 7-128)

Der Maus Monoklonal Anti-Aldehyde Dehydrogenase-Antikörper wurde für WB, IF und IHC validiert. Er ist geeignet, Aldehyde Dehydrogenase in Proben von Human zu detektieren. Es sind 4+ Publikationen verfügbar.
Produktnummer ABIN968411

Kurzübersicht für Aldehyde Dehydrogenase Antikörper (AA 7-128) (ABIN968411)

Target

Alle Aldehyde Dehydrogenase (ALDH) Antikörper anzeigen
Aldehyde Dehydrogenase (ALDH)

Reaktivität

Human

Wirt

  • 8
Maus

Klonalität

  • 8
Monoklonal

Konjugat

  • 5
  • 3
Dieser Aldehyde Dehydrogenase Antikörper ist unkonjugiert

Applikation

  • 8
  • 6
  • 4
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Klon

44-ALDH
  • Bindungsspezifität

    AA 7-128

    Produktmerkmale

    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Please refer to us for technical protocols.

    Aufreinigung

    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

    Immunogen

    Human ALDH1 aa. 7-128

    Isotyp

    IgG1
  • Kommentare

    Related Products: ABIN967389, ABIN968533

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    250 μg/mL

    Buffer

    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store undiluted at -20°C.
  • Zhou, Hanna, Roberts, Weber, Bell: "ALDH1 immunohistochemical expression and its significance in salivary adenoid cystic carcinoma." in: Head & neck, Vol. 35, Issue 4, pp. 575-8, (2013) (PubMed).

    Greene, Bahn, Masson, Rabbitts: "The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development." in: Molecular and cellular biology, Vol. 18, Issue 12, pp. 7030-7, (1998) (PubMed).

    Yoshida, Rzhetsky, Hsu, Chang: "Human aldehyde dehydrogenase gene family." in: European journal of biochemistry / FEBS, Vol. 251, Issue 3, pp. 549-57, (1998) (PubMed).

    Kathmann, Lipsky: "Cloning of a cDNA encoding a constitutively expressed rat liver cytosolic aldehyde dehydrogenase." in: Biochemical and biophysical research communications, Vol. 236, Issue 2, pp. 527-31, (1997) (PubMed).

  • Target

    Aldehyde Dehydrogenase (ALDH)

    Andere Bezeichnung

    ALDH

    Hintergrund

    Aldehyde dehydrogenase (ALDH) is a ubiquitous enzyme located in nearly all mammalian tissues. It catalyzes the irreversible oxidation of a range of aliphatic and aromatic aldehydes to their corresponding carboxylic acids. There are multiple isoforms of ALDH which are subdivided into three classes. Class I includes the cytosolic isoforms. Class II includes the mitochondrial isoforms. Class III includes the microsomal, cytosolic tumor specific, and cytosolic dioxin-inducible forms. At least twelve human ALDH isoforms have been identified. Mutations of many of these proteins such as ALDH1, ALDH2, ALDH4, and ALDH10 have been implicated in multiple human metabolic disorders and clinical abnormalities. At the amino acid level, human ALDH isoforms exhibit a wide range of diversity (15% to about 80%). However, multiple protein regions have been highly conserved and are important for functional activities. A well-characterized member of the human ALDH family is ALDH1. It plays a major role in the biosynthesis of retinoic acid from retinol (vitamin A). Retinoic acid, the biologically active form of retinol, is a regulator of cellular proliferation, differentiation, and survival.

    Molekulargewicht

    55 kDa
Sie sind hier:
Chat with us!