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G3BP1 Antikörper (AA 210-323)

G3BP1 Reaktivität: Human WB, IF Wirt: Maus Monoclonal 23-G3BP unconjugated
Produktnummer ABIN968381
  • Target Alle G3BP1 Antikörper anzeigen
    G3BP1 (GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1))
    Bindungsspezifität
    • 21
    • 8
    • 8
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 210-323
    Reaktivität
    • 75
    • 26
    • 15
    • 8
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    Human
    Wirt
    • 70
    • 4
    • 1
    Maus
    Klonalität
    • 70
    • 5
    Monoklonal
    Konjugat
    • 44
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser G3BP1 Antikörper ist unkonjugiert
    Applikation
    • 68
    • 32
    • 29
    • 17
    • 13
    • 13
    • 11
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Please refer to us for technical protocols.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human G3BP aa. 210-323
    Klon
    23-G3BP
    Isotyp
    IgG1
    Top Product
    Discover our top product G3BP1 Primärantikörper
  • Kommentare

    Related Products: ABIN968552, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Gallouzi, Parker, Chebli, Maurier, Labourier, Barlat, Capony, Tocque, Tazi: "A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability." in: Molecular and cellular biology, Vol. 18, Issue 7, pp. 3956-65, (1998) (PubMed).

    Parker, Maurier, Delumeau, Duchesne, Faucher, Debussche, Dugue, Schweighoffer, Tocque: "A Ras-GTPase-activating protein SH3-domain-binding protein." in: Molecular and cellular biology, Vol. 16, Issue 6, pp. 2561-9, (1996) (PubMed).

  • Target
    G3BP1 (GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1))
    Andere Bezeichnung
    G3BP (G3BP1 Produkte)
    Synonyme
    G3BP antikoerper, HDH-VIII antikoerper, fj17h05 antikoerper, zgc:56034 antikoerper, wu:fj17h05 antikoerper, g3bp antikoerper, MGC53271 antikoerper, G3BP1 antikoerper, G3bp antikoerper, RGD1310666 antikoerper, AI849976 antikoerper, B430204O07 antikoerper, C87777 antikoerper, mKIAA4115 antikoerper, G3BP stress granule assembly factor 1 antikoerper, GTPase activating protein (SH3 domain) binding protein 1 antikoerper, GTPase activating protein (SH3 domain) binding protein 1 L homeolog antikoerper, Ras-GTPase-activating protein SH3-domain-binding protein antikoerper, G3BP1 antikoerper, g3bp1 antikoerper, g3bp1.L antikoerper, LOC100304885 antikoerper, G3bp1 antikoerper
    Hintergrund
    The Ras proteins are low molecular weight GTPases that play a critical role in the control of proliferation, differentiation, and cytoskeletal organization. RasGAP acts as a negative regulator of Ras, as well as a downstream target of Ras. It participates in the signal transduction cascade through interactions with other signaling proteins. Via its C-terminal domain, RasGAP interacts with Ras, but the N-terminus interacts with other signaling molecules such as p62 and p190. This function of RasGAP is mediated by the presence of SH2, SH3, and PH domains in the N-terminal region. However, some signaling proteins cannot bind to these domains. In an attempt to identify RasGAP-interacting molecules, a GAP SH3-Binding Protein (G3BP) was identified. This protein exhibits sequence homology to the hnRNP superfamily. It contains RNP1 and RNP2 motifs and is found primarily in the cytosol. G3BP interacts with GAP in proliferating cells and is dependent on the activation state of Ras. In addition, G3BP contains an intrinsic endonuclease activity that cleaves 3'-untranslated region (3'-UTR) mRNA. These data indicate that G3BP may link the Ras pathway to mRNA degradation.
    Molekulargewicht
    55-70 kDa
    Pathways
    SARS-CoV-2 Protein Interaktom
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