MST1 Antikörper (AA 331-483)

Produktnummer ABIN968344

Dieses Maus Monoklonal-Antikörper erkennt spezifisch MST1 in WB und IF. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für MST1 Antikörper (AA 331-483) (ABIN968344)

Target: MST1 (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MST1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: 7-MST1

Produktdetails anti-MST1 Antikörper

Bindungsspezifität: AA 331-483

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human MST1 aa. 331-483

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968537, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-MST1 Antikörper (ABIN968344)

Lian, Toker, Badwey: "Phosphorylation of the activation loop of gamma p21-activated kinase (gamma-Pak) and related kinases (MSTs) in normal and stressed neutrophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 10, pp. 6349-57, (2001) (PubMed).

Creasy, Chernoff: "Cloning and characterization of a human protein kinase with homology to Ste20." in: The Journal of biological chemistry, Vol. 270, Issue 37, pp. 21695-700, (1995) (PubMed).

Details zu MST1

Target: MST1 (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1))

Andere Bezeichnung: MST1

Hintergrund: Ste20 is a S. cerevisiae Ser/Thr protein kinase that functions upstream of the MAP kinase module. Mammalian and yeast homologs of this kinase are divided into two classes based on their structure and regulation. Members of the first class (Ste20, Cla4, and p21-activated protein kinase [PAK]) contain a C-terminal kinase domain, an N-terminal regulatory domain and a small GTPase Rac1/Cdc42-binding domain. Members of the second class lack GTPase-binding sites, but are similar to the former class throughout the catalytic domain. The latter class includes GC kinase, HPK, KHS, KRS1 & 2, MST1, 2, & 3, and SOK-1. MST1 (Mammalian Sterile Twenty-like-1) is a ubiquitously expressed kinase that contains an N-terminal kinase domain and C-terminal dimerization and inhibitory domains. Apoptotic stimuli, such as anti-Fas, result in cleavage of the C-terminal regulatory domain by caspase-3 or a related caspase, and activation of MST1. Overexpression of MST1 induces caspase activity, apoptotic morphological changes, and the activation of the SAPK and p38 MAPK pathways. Thus, MST1 is thought to function as a component of a positive feedback loop that amplifies the apoptotic response.
Synonyms: Mammalian Sterile Twenty-like 1, Mammalian STE20-like kinase-1

Molekulargewicht: 56 kDa