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NCF2 Antikörper (AA 317-469)

NCF2 Reaktivität: Human, Maus WB, IF Wirt: Maus Monoclonal 29-p67phox unconjugated
Produktnummer ABIN968245
  • Target Alle NCF2 Antikörper anzeigen
    NCF2 (Neutrophil Cytosolic Factor 2 (NCF2))
    Bindungsspezifität
    • 15
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 317-469
    Reaktivität
    • 50
    • 21
    • 18
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 47
    • 2
    • 2
    Maus
    Klonalität
    • 41
    • 10
    Monoklonal
    Konjugat
    • 19
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NCF2 Antikörper ist unkonjugiert
    Applikation
    • 17
    • 13
    • 13
    • 12
    • 10
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Maus
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human p67 [phox] aa. 317-469
    Klon
    29-p67phox
    Isotyp
    IgG2b
    Top Product
    Discover our top product NCF2 Primärantikörper
  • Kommentare

    Related Products: ABIN968584, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Ago, Nunoi, Ito, Sumimoto: "Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating" in: The Journal of biological chemistry, Vol. 274, Issue 47, pp. 33644-53, (1999) (PubMed).

    Benna, Dang, Gaudry, Fay, Morel, Hakim, Gougerot-Pocidalo: "Phosphorylation of the respiratory burst oxidase subunit p67(phox) during human neutrophil activation. Regulation by protein kinase C-dependent and independent pathways." in: The Journal of biological chemistry, Vol. 272, Issue 27, pp. 17204-8, (1997) (PubMed).

    Freeman, Lambeth: "NADPH oxidase activity is independent of p47phox in vitro." in: The Journal of biological chemistry, Vol. 271, Issue 37, pp. 22578-82, (1996) (PubMed).

    Leto, Adams, de Mendez: "Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 22, pp. 10650-4, (1994) (PubMed).

    Leto, Lomax, Volpp, Nunoi, Sechler, Nauseef, Clark, Gallin, Malech: "Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src." in: Science (New York, N.Y.), Vol. 248, Issue 4956, pp. 727-30, (1990) (PubMed).

  • Target
    NCF2 (Neutrophil Cytosolic Factor 2 (NCF2))
    Andere Bezeichnung
    p67 phox (NCF2 Produkte)
    Synonyme
    MGC81877 antikoerper, zgc:158405 antikoerper, noxa2 antikoerper, p67-phox antikoerper, p67phox antikoerper, NCF-2 antikoerper, NOXA2 antikoerper, P67-PHOX antikoerper, P67PHOX antikoerper, Ncf-2 antikoerper, neutrophil cytosolic factor 2 antikoerper, neutrophil cytosolic factor 2 L homeolog antikoerper, neutrophil cytosol factor 2 antikoerper, hypothetical protein antikoerper, NCF2 antikoerper, ncf2.L antikoerper, ncf2 antikoerper, p67phox antikoerper, VDBG_06643 antikoerper, PGTG_05816 antikoerper, LOC100136240 antikoerper, Ncf2 antikoerper
    Hintergrund
    The neutrophil respiratory burst oxidase (NADPH-oxidase) generates superoxide and secondary oxygen-derived toxic products in response to bacteria or a variety of soluble stimuli. The active site of this enzyme is located in an integral membrane cytochrome, b558, that consists of the two subunits gp91 [phox] and p21 [phox]. Superoxide production depends on the formation of a complex that includes p67 [phox], p47 [phox], and the GTP-binding protein Rac. Upon activation, these proteins translocate from the cytosol to the membrane where they assemble with b558 and induce oxidase activity. p67 [phox] contains two SH3 domains and binds, via its C-terminal SH3 domain, to the proline rich region of p47 [phox]. This binding allows p67 [phox] to indirectly associate with the oxidase. It is thought that the phosphorylated forms of p67 [phox] and p47 [phox] interact and that the phosphorylation of p67 [phox] is regulated by both PKC-dependent and independent pathways. Although the role of p67 [phox] in electron flow control is poorly understood, it is thought that it regulates the transfer of electrons from NADPH to reduce flavin.
    Molekulargewicht
    67 kDa
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