TRAF4 Antikörper (AA 2-160)

Produktnummer ABIN968221

Produktdetails anti-TRAF4 Antikörper

Target: TRAF4 (TNF Receptor-Associated Factor 4 (TRAF4))

Bindungsspezifität: AA 2-160

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TRAF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Hund, Ratte (Rattus), Maus

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human CART1 aa. 2-160

Klon: 43-TRAF4

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-TRAF4 Antikörper (ABIN968221)

Bièche, Tomasetto, Régnier, Moog-Lutz, Rio, Lidereau: "Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer." in: Cancer research, Vol. 56, Issue 17, pp. 3886-90, (1996) (PubMed).

Régnier, Tomasetto, Moog-Lutz, Chenard, Wendling, Basset, Rio: "Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma." in: The Journal of biological chemistry, Vol. 270, Issue 43, pp. 25715-21, (1995) (PubMed).

Details zu TRAF4

Target: TRAF4 (TNF Receptor-Associated Factor 4 (TRAF4))

Andere Bezeichnung: TRAF4 (TRAF4 Produkte)

Synonyme: CART1 antikoerper, MLN62 antikoerper, RNF83 antikoerper, A530032M13Rik antikoerper, msp2 antikoerper, traf4 antikoerper, cart1 antikoerper, mln62 antikoerper, rnf83 antikoerper, traf-4 antikoerper, traf4l antikoerper, zgc:77418 antikoerper, TNF receptor associated factor 4 antikoerper, Tnf receptor associated factor 4 antikoerper, tnf receptor-associated factor 4b antikoerper, TNF receptor associated factor 4 L homeolog antikoerper, tnf receptor-associated factor 4a antikoerper, TRAF4 antikoerper, Traf4 antikoerper, traf4b antikoerper, traf4.L antikoerper, traf4a antikoerper

Hintergrund: CART1 gene, located on q11-q12 region of the chromosome 17 long arm, is commonly amplified in human breast carcinomas. The CART1 protein contains several motifs known as the RING, CART, and TRAF domains. The RING domain is cysteine rich (C3HC3D) and is located at the N-terminus. The CART domain is centrally located in the protein and is a cysteine-rich region composed of three repeats of HC3HC3. The TRAF domain is located at the C-terminus and is involved in protein-protein interactions. These domains are also found in the human CD40-binding protein and the mouse TNF receptor-associated factor 2 (TRAF2), which are involved in TNF receptor signaling pathways. CART1 is also known as TRAF4 and is a member of the TRAF family of proteins. TRAF4/CART1 is expressed in breast carcinomas and metastatic axillary lymph nodes, while the mRNA is found in malignant epithelial cells. Immunohistochemistry of a breast carcinoma revealed that TRAF4 is located within the nucleus. Therefore, TRAF4 may play a role in the development of breast carcinomas via TNF-dependent signaling pathways.

Molekulargewicht: 53 kDa