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FKBP1A Antikörper (AA 1-108)

This anti-FKBP1A antibody (ABIN968189) is a Mouse Monoclonal antibody detecting FKBP1A in WB, IHC, IP, IF. Suitable for Human, Mouse, Dog, Chicken.
Produktnummer ABIN968189

Kurzübersicht für FKBP1A Antikörper (AA 1-108) (ABIN968189)

Target

Alle FKBP1A Antikörper anzeigen
FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Reaktivität

  • 65
  • 29
  • 22
  • 7
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Maus, Hund, Huhn

Wirt

  • 65
  • 9
Maus

Klonalität

  • 56
  • 18
Monoklonal

Konjugat

  • 36
  • 10
  • 9
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Dieser FKBP1A Antikörper ist unkonjugiert

Applikation

  • 44
  • 30
  • 19
  • 16
  • 10
  • 8
  • 8
  • 5
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Klon

8-FKBP12
  • Bindungsspezifität

    • 11
    • 9
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-108

    Kreuzreaktivität

    Maus, Hund, Huhn

    Produktmerkmale

    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

    Aufreinigung

    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

    Immunogen

    Human FKBP12 aa. 1-108

    Isotyp

    IgG1
  • Kommentare

    Related Products: ABIN968552, ABIN967389

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    250 μg/mL

    Buffer

    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store undiluted at -20° C.
  • Chen, Liu, Massague: "Mechanism of TGFbeta receptor inhibition by FKBP12." in: The EMBO journal, Vol. 16, Issue 13, pp. 3866-76, (1997) (PubMed).

    Wang, Donahoe, Zervos: "Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12." in: Science (New York, N.Y.), Vol. 265, Issue 5172, pp. 674-6, (1994) (PubMed).

  • Target

    FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

    Andere Bezeichnung

    FKBP12

    Hintergrund

    Transforming growth factor-beta binds to the TGFbeta family of heteromeric serine/threonine transmembrane receptors (type I and type II). Following binding of TGFbeta, the type II receptor (TbetaR-II) phosphorylates the type I receptor (TbetaR-I) which, in turn, conveys the signal. Since TbetaR-I and TbetaR-II can interact without the stimulation of TGFbeta, leading to unwanted activation, a regulatory mechanism exists. In a yeast genetic screen, immunophilin FKBP12 was associated with the type I receptor. Studies including co-immunoprecipiation, deletion, and point mutations confirmed this interaction. FKBP12 inhibits TbetaR-II mediated phosphorylation of TbetaR-I, inhibiting activation. FKBP12 binds via its rapamycin/Leu-Pro binding pocket to the Leu-Pro sequence adjacent to the phosphorylation site of TbetaR-I. This interaction is blocked by the addition of macrolides, rapamycin, and FK506. Furthermore, mutations in the binding sites of FKBP12 and TbetaR-I abrogates the binding and results in activation of the receptor without the addition of TGFbeta. Thus, FKBP12 is a regulatory protein for TbetaR-I and TbetaR-II-mediated signaling.
    Synonyms: FK506 Binding Protein 1A

    Molekulargewicht

    14 kDa

    Pathways

    Negative Regulation of Transporter Activity, Methionine Biosynthetic Process
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