BCL2L1 Antikörper (BCL2-Like 1) (AA 18-233)

Details for Product anti-BCL2L1 Antibody No. ABIN968153, Anbieter: Anmelden zum Anzeigen
Antigen
  • BCL-XL/S
  • BCL2L
  • BCLX
  • BCLXL
  • BCLXS
  • Bcl-X
  • PPP1R52
  • bcl-xL
  • bcl-xS
  • Bcl(X)L
  • Bcl-XL
  • Bcl-Xs
  • Bcl2l
  • BclX
  • bcl-x
  • Bcl-xl
  • Bclx
  • bcl-X
  • Bcl-xL
  • BCL-XL
  • BCL2L1
  • bcl-XL
  • bcl-x(l)
  • bcl-xl/s
  • bcl-xs
  • bcl2l
  • bclx
  • bclxl
  • xR11
  • bcl-xl
  • blp1
  • cb1021
  • zfBLP1
  • BCL2 like 1
  • BCL2-like 1
  • Bcl2-like 1
  • BCL2-like 1 L homeolog
  • bcl2-like 1
  • BCL2L1
  • Bcl2l1
  • bcl2l1
  • bcl2l1.L
Epitop
AA 18-233
144
30
27
27
19
15
15
12
11
10
10
9
9
6
6
5
5
5
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
468
341
311
148
34
19
15
14
13
12
10
7
4
4
2
2
1
Wirt
Maus
288
216
3
2
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser BCL2L1 Antikörper ist unkonjugiert
26
18
12
9
7
7
6
6
6
6
5
5
5
5
5
5
5
2
2
2
2
2
2
2
2
2
1
1
1
Applikation
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
395
202
159
156
152
151
123
95
94
27
10
8
7
7
3
3
2
2
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen Human Bcl-xl aa. 18-233
Klon 44-Bcl
Isotyp IgG1
Kreuzreaktivität Maus, Ratte (Rattus)
Produktmerkmale 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Andere Bezeichnung Bcl-x (BCL2L1 Antibody Abstract)
Hintergrund Bcl-x is related to the Bcl-2 protein and can function independently of Bcl-2 in regulating apoptosis (programmed cell death). The bcl-x transcript is expressed in a number of tissues, with the highest levels in the lymphoid and central nervous systems. Two distinct cDNA species, bcl-xL and bcl-xS, have been observed and appear to arise from alternate 5' splice sites located within the first coding exon of the bcl-x gene. Bcl-xL is composed of 233 amino acids and is similar in size and structure to Bcl-2. The Bcl-xS polypeptide shows a deletion of 63 amino acids which consist of the region of Bcl-xL with the highest degree of amino acid identity to Bcl-2. Like Bcl-2, Bcl-xL inhibits cell death upon growth factor withdrawal when transfected into an IL-3-dependent cell line. However, Bcl-xS inhibits Bcl-2 mediated cell survival.
Molekulargewicht 26 kDa
Pathways Apoptose, Negative Regulation of intrinsic apoptotic Signaling
Kommentare

Related Products: ABIN968536, ABIN967389

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store undiluted at -20° C.
Bilder des Herstellers
Western Blotting (WB) image for anti-BCL2-Like 1 (BCL2L1) (AA 18-233) antibody (ABIN968153) Western blot analysis of Bcl-x on human endothelial cell lysate. Lane 1: 1:500, lane ...
Immunofluorescence (IF) image for anti-BCL2-Like 1 (BCL2L1) (AA 18-233) antibody (ABIN968153) Immunofluorescent staining of Jurkat cells.
 image for anti-BCL2-Like 1 (BCL2L1) (AA 18-233) antibody (ABIN968153) anti-BCL2-Like 1 (BCL2L1) (AA 18-233) antibody (Image 3)
Produkt verwendet in: Devarajan, De Leon, Talasazan, Schoenfeld, Davidowitz, Burk: "The von Hippel-Lindau gene product inhibits renal cell apoptosis via Bcl-2-dependent pathways." in: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 40599-605, 2001 (PubMed).

Oetzel, Jonuleit, Götz, van der Kuip, Michels, Duyster, Hallek, Aulitzky: "The tyrosine kinase inhibitor CGP 57148 (ST1 571) induces apoptosis in BCR-ABL-positive cells by down-regulating BCL-X." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 6, Issue 5, pp. 1958-68, 2000 (PubMed).

Soini, Kinnula, Kaarteenaho-Wiik, Kurttila, Linnainmaa, Pääkkö: "Apoptosis and expression of apoptosis regulating proteins bcl-2, mcl-1, bcl-X, and bax in malignant mesothelioma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 5, Issue 11, pp. 3508-15, 2000 (PubMed).

Kishimoto, Sprent: "Strong TCR ligation without costimulation causes rapid onset of Fas-dependent apoptosis of naive murine CD4+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 4, pp. 1817-26, 1999 (PubMed).

Anderson, Teutsch, Dong, Wortis: "An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 20, pp. 10966-71, 1996 (PubMed).

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