Caveolin 2 Antikörper (AA 42-162)

Produktnummer ABIN968108

Der Maus Monoklonal Anti-Caveolin 2-Antikörper wurde für WB, IHC, IF und IP validiert. Er ist geeignet, Caveolin 2 in Proben von Human, Maus und Ratte zu detektieren. Es sind 6+ Publikationen verfügbar.

Kurzübersicht für Caveolin 2 Antikörper (AA 42-162) (ABIN968108)

Target: Caveolin 2 (CAV2)

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Caveolin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon: 65-Caveolin 2

Produktdetails anti-Caveolin 2 Antikörper

Bindungsspezifität: AA 42-162

Kreuzreaktivität: Maus, Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Caveolin 2 aa. 42-162

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-Caveolin 2 Antikörper (ABIN968108)

Tauchi-Sato, Ozeki, Houjou, Taguchi, Fujimoto: "The surface of lipid droplets is a phospholipid monolayer with a unique Fatty Acid composition." in: The Journal of biological chemistry, Vol. 277, Issue 46, pp. 44507-12, (2002) (PubMed).

Woodman, Park, Cohen, Cheung, Chandra, Shirani, Tang, Jelicks, Kitsis, Christ, Factor, Tanowitz, Lisanti: "Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38988-97, (2002) (PubMed).

Zschocke, Manthey, Bayatti, van der Burg, Goodenough, Behl: "Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cells." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38772-80, (2002) (PubMed).

Kiss, Túri, Müllner, Tímár: "Caveolin isoforms in resident and elicited rat peritoneal macrophages." in: European journal of cell biology, Vol. 79, Issue 5, pp. 343-9, (2000) (PubMed).

Das, Lewis, Scherer, Lisanti: "The membrane-spanning domains of caveolins-1 and -2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo." in: The Journal of biological chemistry, Vol. 274, Issue 26, pp. 18721-8, (1999) (PubMed).

Scherer, Okamoto, Chun, Nishimoto, Lodish, Lisanti: "Identification, sequence, and expression of caveolin-2 defines a caveolin gene family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 1, pp. 131-5, (1996) (PubMed).

Details zu Caveolin 2

Target: Caveolin 2 (CAV2)

Andere Bezeichnung: Caveolin 2

Hintergrund: Identified as a tyrosine phosphorylated protein in Rous sarcoma virus- transformed chick embryo fibroblasts (CEF), caveolin is now known to be ubiquitously expressed. Caveolin (also known as VIP21) localizes to non-clathrin membrane invaginations (caveolae) on the inner surface of the plasma membrane. This transmembrane protein plays a structural role in these specializations. Caveolin is also present at the trans-Golgi network (TGN) and similar quantities are found in apically and basolaterally destined transport vesicles. Caveolin is part of a complex containing glycosylphosphatidylinositol (GPI)-linked molecules and cytoplasmic signaling proteins. Caveolin is a transmembrane adaptor molecule that can simultaneously recognize GPI-linked proteins and interact with downstream cytoplasmic signaling molecules, such as c-yes, Annexin II, and hetero-trimeric G proteins. Although caveolin 2 is similar to caveolin 1 in distribution and tissue expression, caveolin 2 is most abundant in adipose tissue and its expression is up-regulated upon differentiation. This antibody has been reported to recognize an epitope located within region 79-88 of caveolin 2.

Molekulargewicht: 20 kDa

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development