FKBP10 Antikörper (AA 434-576)

Produktnummer ABIN968087

Der Maus Monoklonal Anti-FKBP10-Antikörper wurde für WB, IHC, IP und IF validiert. Er ist geeignet, FKBP10 in Proben von Human, Maus und Ratte zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für FKBP10 Antikörper (AA 434-576) (ABIN968087)

Target: FKBP10 (FK506 Binding Protein 10, 65 KDa (FKBP10))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FKBP10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Klon: 25-FKBP65

Produktdetails anti-FKBP10 Antikörper

Bindungsspezifität: AA 434-576

Kreuzreaktivität: Ratte (Rattus), Human

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse FKBP65 aa. 434-576

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389, ABIN968539

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-FKBP10 Antikörper (ABIN968087)

Patterson, Schaub, Coleman, Davis: "Developmental regulation of FKBP65. An ER-localized extracellular matrix binding-protein." in: Molecular biology of the cell, Vol. 11, Issue 11, pp. 3925-35, (2001) (PubMed).

Coss, Winterstein, Sowder, Simek: "Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65)." in: The Journal of biological chemistry, Vol. 270, Issue 49, pp. 29336-41, (1996) (PubMed).

Details zu FKBP10

Target: FKBP10 (FK506 Binding Protein 10, 65 KDa (FKBP10))

Andere Bezeichnung: FKBP65

Hintergrund: FK506, one of multiple potent compounds that block T cell proliferation, is used for immunosuppressive therapy. Several FK506-binding proteins (FKBPs) have been identified in the search for intracellular targets for FK506. These include FKBP12, FKBP13, FKBP51, and FKBP52. The immunosuppressive effects of FK506 and FKBPs result from the inhibition of the calcineurin phosphatase, a well known component of the signaling cascade leading to IL-2 production. FKBP65 is another member of the FKBP protein family and contains the characteristic peptidylprolyl cis-trans-isomerase activity. FKBP65 has been reported to be expressed in the lung, testis, brain, heart, and spleen. Although it has a predicted molecular weight of 65 kDa, FKBP65 has been observed to migrate ranging from 68-72 kDa in SDS electrophoresis gels, perhaps, due to glycosylation and/or phosphorylation.
Synonyms: FK506 Binding Protein-65

Molekulargewicht: 68-72 kDa

Pathways: SARS-CoV-2 Protein Interaktom