Syntaxin 6 Antikörper (AA 6-136)

Produktnummer ABIN968080

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Syntaxin 6 in WB, IHC, IF und IP. Er zeigt eine Reaktivität gegenüber Human, Huhn, Maus, Ratte, Hund und Frosch und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für Syntaxin 6 Antikörper (AA 6-136) (ABIN968080)

Target: Syntaxin 6 (STX6)

Reaktivität: Human, Huhn, Maus, Ratte, Hund, Frosch

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Syntaxin 6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon: 30-Syntaxin 6

Produktdetails anti-Syntaxin 6 Antikörper

Bindungsspezifität: AA 6-136

Kreuzreaktivität: Human, Maus, Hund, Huhn, Frosch

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat Syntaxin 6 aa. 6-136

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968533, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-Syntaxin 6 Antikörper (ABIN968080)

Shewan, van Dam, Martin, Luen, Hong, Bryant, James: "GLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif." in: Molecular biology of the cell, Vol. 14, Issue 3, pp. 973-86, (2003) (PubMed).

Mullock, Smith, Ihrke, Bright, Lindsay, Parkinson, Brooks, Parton, James, Luzio, Piper: "Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion." in: Molecular biology of the cell, Vol. 11, Issue 9, pp. 3137-53, (2000) (PubMed).

Ramalho-Santos, Moreno, Sutovsky, Chan, Hewitson, Wessel, Simerly, Schatten: "SNAREs in mammalian sperm: possible implications for fertilization." in: Developmental biology, Vol. 223, Issue 1, pp. 54-69, (2000) (PubMed).

Bock, Lin, Scheller: "A new syntaxin family member implicated in targeting of intracellular transport vesicles." in: The Journal of biological chemistry, Vol. 271, Issue 30, pp. 17961-5, (1996) (PubMed).

Details zu Syntaxin 6

Target: Syntaxin 6 (STX6)

Andere Bezeichnung: Syntaxin 6

Hintergrund: Signal transmission between cells is often regulated by the secretion of neurotransmitters or hormones into the extracellular space. This process is controlled by a complex pathway of membrane trafficking which leads to membrane fusion and secretion. Syntaxin 1 is involved in three important complexes that modulate the secretion process: syntaxin and n-sec-1, syntaxin, VAMP, and SNAP-25, and syntaxin, VAMP, SNAP-25, alphaSNAP, and NSF (20S complex). Syntaxin 6 is a 255 amino acid member of the syntaxin family. It contains a C-terminal transmembrane domain and is located at the Golgi apparatus. In addition, Syntaxin 6 displays significant (47% identity) homology with SNAP-25. In vitro, Syntaxin 6 has been reported to interact with alpha-SNAP. Syntaxin 6 has been reported to have a calculated molecular weight of 30.6 kDa, but has been observed to migrate in a range inbetween ~ 31-35 kDa.

Molekulargewicht: 31-35 kDa

Pathways: Synaptic Vesicle Exocytosis