GLN1 Antikörper (AA 1-373)

Produktnummer ABIN968015

Der Maus Monoklonal Anti-GLN1-Antikörper wurde für WB, IHC, IP, IF und BI validiert. Er ist geeignet, GLN1 in Proben von Human, Maus und Ratte zu detektieren. Es sind 7+ Publikationen verfügbar.

Kurzübersicht für GLN1 Antikörper (AA 1-373) (ABIN968015)

Target: GLN1 (Glutamine Synthetase (GLN1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GLN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), BioImaging (BI)

Klon: 6-Glutamine Synthetase

Produktdetails anti-GLN1 Antikörper

Bindungsspezifität: AA 1-373

Kreuzreaktivität: Ratte (Rattus), Human, Maus

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Glutamine Synthetase aa. 1-373

Isotyp: IgG2a

Anwendungsinformationen

Kommentare:

Related Products: ABIN968545, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-GLN1 Antikörper (ABIN968015)

De Sevilla Müller, Liu, Solomon, Rodriguez, Brecha: "Expression of voltage-gated calcium channel α(2)δ(4) subunits in the mouse and rat retina." in: The Journal of comparative neurology, Vol. 521, Issue 11, pp. 2486-501, (2013) (PubMed).

OBrien, Caldwell, Ehring, Bumsted OBrien, Luo, Levinson: "Tetrodotoxin-resistant voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 are expressed in the retina." in: The Journal of comparative neurology, Vol. 508, Issue 6, pp. 940-51, (2008) (PubMed).

Kronfeld, Kazimirsky, Lorenzo, Garfield, Blumberg, Brodie: "Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions." in: The Journal of biological chemistry, Vol. 275, Issue 45, pp. 35491-8, (2000) (PubMed).

Labow, Souba, Abcouwer: "Glutamine synthetase expression in muscle is regulated by transcriptional and posttranscriptional mechanisms." in: The American journal of physiology, Vol. 276, Issue 6 Pt 1, pp. E1136-45, (1999) (PubMed).

Fei, DAmbrosio, Li, Surmacz, Baserga: "Association of insulin receptor substrate 1 with simian virus 40 large T antigen." in: Molecular and cellular biology, Vol. 15, Issue 8, pp. 4232-39, (1995) (PubMed).

Kentroti, Baker, Lee, Bruce, Vernadakis: "Platelet-activating factor increases glutamine synthetase activity in early and late passage C-6 glioma cells." in: Journal of neuroscience research, Vol. 28, Issue 4, pp. 497-506, (1991) (PubMed).

Vardimon, Fox, Cohen-Kupiec, Degenstein, Moscona: "Expression of v-src in embryonic neural retina alters cell adhesion, inhibits histogenesis, and prevents induction of glutamine synthetase." in: Molecular and cellular biology, Vol. 11, Issue 10, pp. 5275-84, (1991) (PubMed).

Details zu GLN1

Target: GLN1 (Glutamine Synthetase (GLN1))

Andere Bezeichnung: Glutamine Synthetase

Hintergrund: Glutamine synthetase catalyzes the amination of glutamic acid to form glutamine. It is found in mammals as an octamer of identical 45 kDa subunits. Glutamine synthetase activity is a useful marker for astrocytes and an important differentiation feature in retina. It is also considered to be a key enzyme in the recycling of the neurotransmitter glutamate. This antibody is routinely tested by western blot analysis.

Molekulargewicht: 45 kDa

Pathways: Positive Regulation of Peptide Hormone Secretion