MVP Antikörper (AA 403-592)

Produktnummer ABIN968013

Dieses Anti-MVP-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von MVP in WB, IHC, IF und IP. Geeignet für Human, Rind (Kuh), Kaninchen und Hund. Dieses Primary Antibody wurde in 5+ Publikationen zitiert.

Kurzübersicht für MVP Antikörper (AA 403-592) (ABIN968013)

Target: MVP (Major Vault Protein (MVP))

Reaktivität: Human, Rind (Kuh), Kaninchen, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MVP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon: 42-LRP

Produktdetails anti-MVP Antikörper

Bindungsspezifität: AA 403-592

Kreuzreaktivität: Rind (Kuh), Hund, Kaninchen

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human LRP aa. 403-592

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389, ABIN968536

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-MVP Antikörper (ABIN968013)

Papura: "Managed care policy regarding OMT reimbursement illogical." in: The Journal of the American Osteopathic Association, Vol. 102, Issue 2, pp. 66, (2002) (PubMed).

Rybarova, Batekova, Hodorova, Mirossay, Kluchova, Bobrov, Kocisova: "Immunohistochemical detection of LRP protein in the normal human lung." in: Bratislavské lekárske listy, Vol. 102, Issue 2, pp. 66-72, (2001) (PubMed).

List, Spier, Grogan, Johnson, Roe, Greer, Wolff, Broxterman, Scheffer, Scheper, Dalton: "Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia." in: Blood, Vol. 87, Issue 6, pp. 2464-9, (1996) (PubMed).

Kickhoefer, Rome: "The sequence of a cDNA encoding the major vault protein from Rattus norvegicus." in: Gene, Vol. 151, Issue 1-2, pp. 257-60, (1995) (PubMed).

Scheffer, Wijngaard, Flens, Izquierdo, Slovak, Pinedo, Meijer, Clevers, Scheper: "The drug resistance-related protein LRP is the human major vault protein." in: Nature medicine, Vol. 1, Issue 6, pp. 578-82, (1995) (PubMed).

Details zu MVP

Target: MVP (Major Vault Protein (MVP))

Andere Bezeichnung: LRP

Hintergrund: Drugs that selectively attack dividing cells are often used in cancer therapy. However, small cell populations do not die, but develop resistance to a variety of toxic drugs. Multidrug resistance is achieved by gene amplification of specific membrane-bound transport ATPases that shuttle the drugs out of cells. Some multidrug-resistant cancer cells express a protein of 110 kDa named LRP (Lung Resistance-related Protein). LRP expression might be an indicator of prognosis after chemotherapy in acute myeloid leukemia and ovarian carcinoma. The LRP gene encodes a protein of 896 amino acids with significant homology to the major vault protein from Dictyostelium discoideum. Although ubiquitously expressed, LRP is most abundant in epithelial cells.

Molekulargewicht: 110 kDa