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BCAR1 Antikörper (AA 644-819)

BCAR1 Reaktivität: Human, Maus, Ratte, Hund, Huhn WB, IF, IP, IHC (f) Wirt: Maus Monoclonal 21-p130[Cas] unconjugated
Produktnummer ABIN967871
  • Target Alle BCAR1 Antikörper anzeigen
    BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))
    Bindungsspezifität
    • 28
    • 23
    • 15
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 644-819
    Reaktivität
    • 112
    • 62
    • 51
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Huhn
    Wirt
    • 117
    • 11
    • 2
    • 1
    Maus
    Klonalität
    • 122
    • 9
    Monoklonal
    Konjugat
    • 63
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    Dieser BCAR1 Antikörper ist unkonjugiert
    Applikation
    • 56
    • 40
    • 39
    • 39
    • 25
    • 23
    • 13
    • 10
    • 9
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Kreuzreaktivität
    Human, Huhn, Hund, Maus
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Rat p130 [Cas] aa. 644-819
    Klon
    21-p130[Cas]
    Isotyp
    IgG1
    Top Product
    Discover our top product BCAR1 Primärantikörper
  • Kommentare

    Related Products: ABIN968536, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Hermanto, Zong, Li, Wang: "RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix." in: Molecular and cellular biology, Vol. 22, Issue 7, pp. 2345-65, (2002) (PubMed).

    Nagashima, Endo, Ogita, Kawana, Yamagishi, Kitabatake, Matsuda, Mochizuki: "Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells." in: Molecular biology of the cell, Vol. 13, Issue 12, pp. 4231-42, (2002) (PubMed).

    Derkinderen, Toutant, Kadaré, Ledent, Parmentier, Girault: "Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus." in: The Journal of biological chemistry, Vol. 276, Issue 41, pp. 38289-96, (2001) (PubMed).

    Kook, Shim, Choi, Ahnn, Kim, Eom, Jung, Paik, Song: "Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells." in: Molecular biology of the cell, Vol. 11, Issue 3, pp. 929-39, (2000) (PubMed).

  • Target
    BCAR1 (Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))
    Andere Bezeichnung
    p130 Cas (BCAR1 Produkte)
    Synonyme
    CAS antikoerper, CAS1 antikoerper, CASS1 antikoerper, CRKAS antikoerper, P130Cas antikoerper, AI385681 antikoerper, Cas antikoerper, Crkas antikoerper, P130CAS antikoerper, MGC68466 antikoerper, cas antikoerper, p130cas antikoerper, BCAR1 antikoerper, fc17f11 antikoerper, wu:fc17f11 antikoerper, zgc:175192 antikoerper, BCAR1, Cas family scaffolding protein antikoerper, breast cancer anti-estrogen resistance 1 antikoerper, breast cancer anti-estrogen resistance 1 L homeolog antikoerper, breast cancer anti-estrogen resistance protein 1 antikoerper, BCAR1 antikoerper, Bcar1 antikoerper, bcar1.L antikoerper, bcar1 antikoerper, LOC100435586 antikoerper
    Hintergrund
    P47 [v-crk] is the product of a transforming gene, v-crk, that was isolated from avian sarcoma viruses. The v-crk protein is a fusion product of the viral gag protein and a part of cellular crk that includes SH2 and SH3 domains. v-crk induced transformation increases tyrosine phosphorylation of several cellular proteins, including p130 [Cas]. p130 [Cas] is tightly associated with v-crk via the SH2 domain of v-crk. Tyrosine phosphorylation of p130 [Cas] occurs in conjunction with cellular transformation in cells that express v-src or v-crk. This phosphorylation leads to a change in p130 [Cas] localization from the cytoplasm to the cell membrane and, possibly, to the nucleus. Since p130 [Cas] also associates with v-src, it may be a v-src substrate. This antibody is routinely tested by western blot analysis.
    Molekulargewicht
    130 kDa
    Pathways
    EGFR Signaling Pathway, Neurotrophin Signalübertragung, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
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