RBP4 Antikörper (AA 1-135)

Produktnummer ABIN967847

Produktdetails anti-RBP4 Antikörper

Target: RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

Bindungsspezifität: AA 1-135

Reaktivität: Human, Maus, Ratte, Huhn, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RBP4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Kreuzreaktivität: Hund, Huhn, Maus, Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human RBP aa. 1-135

Klon: 42-RBP

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389, ABIN968619

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-RBP4 Antikörper (ABIN967847)

Christensen, Moskaug, Vorum, Jacobsen, Gundersen, Nykjaer, Blomhoff, Willnow, Moestrup: "Evidence for an essential role of megalin in transepithelial transport of retinol." in: Journal of the American Society of Nephrology : JASN, Vol. 10, Issue 4, pp. 685-95, (1999) (PubMed).

Zanotti, Berni, Monaco: "Crystal structure of liganded and unliganded forms of bovine plasma retinol-binding protein." in: The Journal of biological chemistry, Vol. 268, Issue 15, pp. 10728-38, (1993) (PubMed).

Zanotti, Malpeli, Berni: "The interaction of N-ethyl retinamide with plasma retinol-binding protein (RBP) and the crystal structure of the retinoid-RBP complex at 1.9-A resolution." in: The Journal of biological chemistry, Vol. 268, Issue 33, pp. 24873-9, (1993) (PubMed).

Zanotti, Ottonello, Berni, Monaco: "Crystal structure of the trigonal form of human plasma retinol-binding protein at 2.5 A resolution." in: Journal of molecular biology, Vol. 230, Issue 2, pp. 613-24, (1993) (PubMed).

Blomhoff, Green, Berg, Norum: "Transport and storage of vitamin A." in: Science (New York, N.Y.), Vol. 250, Issue 4979, pp. 399-404, (1990) (PubMed).

Details zu RBP4

Target: RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

Andere Bezeichnung: RBP (RBP4 Produkte)

Synonyme: RDCCAS antikoerper, RBP antikoerper, RNBP antikoerper, rbp4 antikoerper, MGC54038 antikoerper, srbp antikoerper, PRBP antikoerper, RBPA antikoerper, Rbp-4 antikoerper, fb23c12 antikoerper, rbp antikoerper, wu:fb23c12 antikoerper, wu:fb58d04 antikoerper, wu:fb72b04 antikoerper, zgc:86911 antikoerper, retinol binding protein 4 antikoerper, renin binding protein antikoerper, retinol binding protein 4 S homeolog antikoerper, retinol binding protein 4 A, plasma antikoerper, retinol binding protein 4, plasma antikoerper, retinol binding protein 4 L homeolog antikoerper, RBP4 antikoerper, RENBP antikoerper, rbp4.S antikoerper, rbp4 antikoerper, Rbp4 antikoerper, RBP4A antikoerper, rbp4.L antikoerper

Hintergrund: Retinol, a metabolic precursor of retinal and retinoic acid, is transported in plasma bound to a carrier protein known as retinol-binding protein (RBP). RBP is the only retinoid-specific binding protein that has been identified in plasma. The presence of RBP increases the stability of retinol as it is transported from its stores to target cells. In plasma, the 21 kDa RBP forms a tight complex with thyroxine-binding transthyretin (TTR), a homotetramer of about 55 kDa. Association of RBP with TTR increases the stability of the retinol-RBP complex. It is believed that this association prevents filtration of the relatively small RBP through the kidney glomeruli. Once retinol is delivered to its target cells, the resulting retinol-free RBP has a reduced affinity for TTR and thus can be selectively cleared from the circulation by filtration through kidney glomeruli. The three dimensional structures of human and bovine RBP have been compared and appear to be very similar.

Molekulargewicht: 21 kDa

Pathways: Regulatorische RNA Pathways, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response