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RBP4 Antikörper (AA 1-135)

Der Maus Monoklonal Anti-RBP4-Antikörper wurde für WB, IHC, IP und IF validiert. Er ist geeignet, RBP4 in Proben von Human, Maus, Ratte, Huhn und Hund zu detektieren. Es sind 5+ Publikationen verfügbar.
Produktnummer ABIN967847

Kurzübersicht für RBP4 Antikörper (AA 1-135) (ABIN967847)

Target

Alle RBP4 Antikörper anzeigen
RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

Reaktivität

  • 137
  • 43
  • 27
  • 17
  • 14
  • 11
  • 10
  • 7
  • 7
  • 5
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte, Huhn, Hund

Wirt

  • 148
  • 54
  • 8
  • 5
  • 1
  • 1
Maus

Klonalität

  • 157
  • 60
Monoklonal

Konjugat

  • 124
  • 33
  • 21
  • 7
  • 5
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
Dieser RBP4 Antikörper ist unkonjugiert

Applikation

  • 138
  • 105
  • 69
  • 58
  • 38
  • 29
  • 23
  • 11
  • 11
  • 7
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Klon

42-RBP
  • Bindungsspezifität

    • 22
    • 16
    • 8
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-135

    Kreuzreaktivität

    Hund, Huhn, Maus, Ratte (Rattus)

    Produktmerkmale

    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

    Aufreinigung

    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

    Immunogen

    Human RBP aa. 1-135

    Isotyp

    IgG1
  • Kommentare

    Related Products: ABIN967389, ABIN968619

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    250 μg/mL

    Buffer

    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store undiluted at -20°C.
  • Christensen, Moskaug, Vorum, Jacobsen, Gundersen, Nykjaer, Blomhoff, Willnow, Moestrup: "Evidence for an essential role of megalin in transepithelial transport of retinol." in: Journal of the American Society of Nephrology : JASN, Vol. 10, Issue 4, pp. 685-95, (1999) (PubMed).

    Zanotti, Berni, Monaco: "Crystal structure of liganded and unliganded forms of bovine plasma retinol-binding protein." in: The Journal of biological chemistry, Vol. 268, Issue 15, pp. 10728-38, (1993) (PubMed).

    Zanotti, Malpeli, Berni: "The interaction of N-ethyl retinamide with plasma retinol-binding protein (RBP) and the crystal structure of the retinoid-RBP complex at 1.9-A resolution." in: The Journal of biological chemistry, Vol. 268, Issue 33, pp. 24873-9, (1993) (PubMed).

    Zanotti, Ottonello, Berni, Monaco: "Crystal structure of the trigonal form of human plasma retinol-binding protein at 2.5 A resolution." in: Journal of molecular biology, Vol. 230, Issue 2, pp. 613-24, (1993) (PubMed).

    Blomhoff, Green, Berg, Norum: "Transport and storage of vitamin A." in: Science (New York, N.Y.), Vol. 250, Issue 4979, pp. 399-404, (1990) (PubMed).

  • Target

    RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

    Andere Bezeichnung

    RBP

    Hintergrund

    Retinol, a metabolic precursor of retinal and retinoic acid, is transported in plasma bound to a carrier protein known as retinol-binding protein (RBP). RBP is the only retinoid-specific binding protein that has been identified in plasma. The presence of RBP increases the stability of retinol as it is transported from its stores to target cells. In plasma, the 21 kDa RBP forms a tight complex with thyroxine-binding transthyretin (TTR), a homotetramer of about 55 kDa. Association of RBP with TTR increases the stability of the retinol-RBP complex. It is believed that this association prevents filtration of the relatively small RBP through the kidney glomeruli. Once retinol is delivered to its target cells, the resulting retinol-free RBP has a reduced affinity for TTR and thus can be selectively cleared from the circulation by filtration through kidney glomeruli. The three dimensional structures of human and bovine RBP have been compared and appear to be very similar.

    Molekulargewicht

    21 kDa

    Pathways

    Regulatorische RNA Pathways, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response
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