ROR gamma T/RORC2/NR1F3 Antikörper

Produktnummer ABIN967684

Dieses Maus Monoklonal-Antikörper erkennt spezifisch in WB. Er zeigt eine Reaktivität gegenüber Human und Maus und wurde in 6+ Publikationen erwähnt.

Kurzübersicht für ROR gamma T/RORC2/NR1F3 Antikörper (ABIN967684)

Target: ROR gamma T/RORC2/NR1F3

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Klon: O28-835

Produktdetails

Marke: BD Pharmingen™

Kreuzreaktivität: Maus

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human RORgammat Recombinant Protein

Isotyp: IgG2b kappa

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen

Hamada, Garcia-Hernandez, Reome, Misra, Strutt, McKinstry, Cooper, Swain, Dutton: "Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 6, pp. 3469-81, (2009) (PubMed).

Ivanov, McKenzie, Zhou, Tadokoro, Lepelley, Lafaille, Cua, Littman: "The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells." in: Cell, Vol. 126, Issue 6, pp. 1121-33, (2006) (PubMed).

Eberl, Littman: "The role of the nuclear hormone receptor RORgammat in the development of lymph nodes and Peyer's patches." in: Immunological reviews, Vol. 195, Issue 9, pp. 81-90, (2003) (PubMed).

Eberl, Marmon, Sunshine, Rennert, Choi, Littman: "An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells." in: Nature immunology, Vol. 5, Issue 1, pp. 64-73, (2003) (PubMed).

He, Deftos, Ojala, Bevan: "RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells." in: Immunity, Vol. 9, Issue 6, pp. 797-806, (1999) (PubMed).

Medvedev, Yan, Hirose, Giguère, Jetten: "Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element." in: Gene, Vol. 181, Issue 1-2, pp. 199-206, (1997) (PubMed).

Antigendetails

Target: ROR gamma T/RORC2/NR1F3

Andere Bezeichnung: ROR GAM T

Hintergrund: The O28-835 monoclonal antibody recognizes ROR-gamma (RORgamma) and its isoform, RORgammat. RORgamma (~58 kDa calculated molecular weight) is a DNA-binding transcription factor that belongs to the ROR/RZR orphan nuclear receptor family. It is expressed in different tissues including skeletal muscle, kidney, liver and adipose tissues. RORgammat (~56 kDa calculated molecular weight) is a RORgamma isoform that is expressed exclusively by lymphoid cells. It is expressed by various lymphoid cell types including CD4+CD8+ thymocytes, peripheral CD4+ Th17 and CD8+ Tc17 cells and lymphoid tissue inducer (Lti) cells. RORgammat plays essential roles in thymopoiesis, T cell homeostasis, differentiation of effector T lymphocytes and the development of secondary lymphoid tissues including lymph nodes and Peyer’s patches.
Synonyms: Rorc, Rorg, RORgamma, Rorgamma, RORgt, RORgammat, RORgammat, TOR, Thor, Nr1f3, ROR

Molekulargewicht: 56-58 kDa