KAT5 Antikörper

Produktnummer ABIN967184

Der Monoklonal Anti-KAT5-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, KAT5 in Proben von Human zu detektieren.

Kurzübersicht für KAT5 Antikörper (ABIN967184)

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Monoklonal

Konjugat: Dieser KAT5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-KAT5 Antikörper

Aufreinigung: Crude ascites.

Immunogen: Ni-NTA purified truncated recombinant TIP60-gst expressed in E. Coli strain BL21 (DE3)

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -20 °C

Details zu KAT5

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Andere Bezeichnung: TIP60

Hintergrund: HTATIP (HIV-1 Tat interacting protein TIP60, about 60kDa) belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. In addition to the growing number of post-translational histone modifications regulating chromatin structure, cells can also exchange canonical histones with variant histones that can directly or indirectly modulate chromatin structure. There are five major variants of histone H2A: canonical H2A (most abundant), H2A.X, MacroH2A, H2ABbd and H2A.Z. Histone H2A.Z, the most conserved variant across species, functions as both a positive and negative regulator of transcription and is important for chromosome stability. Several homologous protein complexes, such as SWR-C, TIP60 and SRCAP (mammals), have been shown to catalyze the ATPdependent exchange of H2A.Z for H2A in the nucleosome. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

Gen-ID: 10524

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway