SYNPO Antikörper (AA 495-509)

Produktnummer ABIN967124

Der Polyklonal Anti-SYNPO-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, SYNPO in Proben von Human und Ratte zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für SYNPO Antikörper (AA 495-509) (ABIN967124)

Target: SYNPO (Synaptopodin (SYNPO))

Reaktivität: Human, Ratte

Wirt: Bitte anfragen

Klonalität: Polyklonal

Konjugat: Dieser SYNPO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-SYNPO Antikörper

Bindungsspezifität: AA 495-509

Immunogen: A synthetic peptide corresponding to a sequence at the middle region of human synaptopodin (495-509 aa), identical to the related mouse and rat sequence.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Lagerung: -20 °C

Referenzen für anti-SYNPO Antikörper (ABIN967124)

Cooney, Hurlburt, Selig, Harris, Fiala: "Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 6, pp. 2215-24, (2002) (PubMed).

Deller, Merten, Roth, Mundel, Frotscher: "Actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons." in: The Journal of comparative neurology, Vol. 418, Issue 2, pp. 164-81, (2000) (PubMed).

GRAY: "Electron microscopy of synaptic contacts on dendrite spines of the cerebral cortex." in: Nature, Vol. 183, Issue 4675, pp. 1592-3, (1959) (PubMed).

Details zu SYNPO

Target: SYNPO (Synaptopodin (SYNPO))

Andere Bezeichnung: Synaptopodin

Hintergrund: The spine apparatus (SA) is a specialized form of endoplasmic reticulum (ER) that is found in a subpopulation of dendritic spines in central neurons. The SA consists of a series of stacked discs that are thought to be connected to each other and to the dendritic system of ER-tubules. The actin binding protein synaptopodin (which has originally been described in podocytes of the kidney) is an essential component of the SA. Mice that lack the gene for synaptopodin do not form a spine apparatus. The SA is believed to play a critical role in learning and memory. In summary, an important function of the spine apparatus is the regulation of plasticity at individual synapses, a process known as metaplasticity. The International Radiation Hybrid Mapping Consortium mapped the SYNPO gene to chromosome 5.