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SLUG Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SLUG in IHC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 5+ Publikationen erwähnt.
Produktnummer ABIN967057

Kurzübersicht für SLUG Antikörper (C-Term) (ABIN967057)

Target

Alle SLUG (SNAI2) Antikörper anzeigen
SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Reaktivität

  • 50
  • 18
  • 13
  • 4
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 38
  • 12
Kaninchen

Klonalität

  • 39
  • 10
Polyklonal

Konjugat

  • 32
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Dieser SLUG Antikörper ist unkonjugiert

Applikation

  • 27
  • 19
  • 12
  • 9
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Immunogen

    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to near C-terminal residues of human SNAI2
  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Lagerung

    4 °C
  • Larriba, Martín-Villar, García, Pereira, Peña, de Herreros, Bonilla, Muñoz: "Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer." in: Carcinogenesis, Vol. 30, Issue 8, pp. 1459-68, (2009) (PubMed).

    Wang, Wang, Chang, Wu, Chao, Kao, Yuan, Lin, Yang, Chan, Li, Hong, Yang: "p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug." in: Nature cell biology, Vol. 11, Issue 6, pp. 694-704, (2009) (PubMed).

    Saegusa, Hashimura, Kuwata, Okayasu: "Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, (2009) (PubMed).

    Hemavathy, Guru, Harris, Chen, Ip: "Human Slug is a repressor that localizes to sites of active transcription." in: Molecular and cellular biology, Vol. 20, Issue 14, pp. 5087-95, (2000) (PubMed).

    Inukai, Inoue, Kurosawa, Goi, Shinjyo, Ozawa, Mao, Inaba, Look: "SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein." in: Molecular cell, Vol. 4, Issue 3, pp. 343-52, (1999) (PubMed).

  • Target

    SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

    Andere Bezeichnung

    SNAI2

    Hintergrund

    SNAI2 is a member of the Snail family of C2H2-type zinc finger transcription factors. The SNAI2 protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress Ecadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this SNAI2 gene may be associated with sporatic cases of neural tube defects.
    Synonyms: MGC10182, SLUG, SLUGH1, WS2D
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