SIRT6 Antikörper (C-Term)

Produktnummer ABIN967032

Dieses Anti-SIRT6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SIRT6 in IHC. Geeignet für Human. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.

Kurzübersicht für SIRT6 Antikörper (C-Term) (ABIN967032)

Target: SIRT6 (Sirtuin 6 (SIRT6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRT6 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-SIRT6 Antikörper

Bindungsspezifität: C-Term

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Referenzen für anti-SIRT6 Antikörper (ABIN967032)

Kawahara, Michishita, Adler, Damian, Berber, Lin, McCord, Ongaigui, Boxer, Chang, Chua: "SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span." in: Cell, Vol. 136, Issue 1, pp. 62-74, (2009) (PubMed).

Michishita, McCord, Berber, Kioi, Padilla-Nash, Damian, Cheung, Kusumoto, Kawahara, Barrett, Chang, Bohr, Ried, Gozani, Chua: "SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin." in: Nature, Vol. 452, Issue 7186, pp. 492-6, (2008) (PubMed).

Kanfi, Shalman, Peshti, Pilosof, Gozlan, Pearson, Lerrer, Moazed, Marine, de Cabo, Cohen: "Regulation of SIRT6 protein levels by nutrient availability." in: FEBS letters, Vol. 582, Issue 5, pp. 543-8, (2008) (PubMed).

Details zu SIRT6

Target: SIRT6 (Sirtuin 6 (SIRT6))

Andere Bezeichnung: SIRT6

Hintergrund: SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6) is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT6 (Mono-ADPribosyltransferase sirtuin-6) is included in class IV of the sirtuin family. SIRT6 (Mono-ADPribosyltransferase sirtuin-6) contains 1 deacetylase sirtuin-type domain.
Synonyms: SIR2L6(SIR2-like protein 6)