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SasG Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-SasG-Antikörper wurde für IHC validiert. Er ist geeignet, SasG in Proben von Staphylococcus aureus zu detektieren.
Produktnummer ABIN966995

Kurzübersicht für SasG Antikörper (C-Term) (ABIN966995)

Target

SasG (SASG) (SasG Gene Product (SASG))

Reaktivität

Staphylococcus aureus

Wirt

Kaninchen

Klonalität

Polyklonal

Applikation

Immunohistochemistry (IHC)
  • Bindungsspezifität

    C-Term

    Immunogen

    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of Bacteria: Staphylococcus aureus SasG (Surface protein G)
  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Lagerung

    4 °C
  • Target

    SasG (SASG) (SasG Gene Product (SASG))

    Andere Bezeichnung

    SasG

    Hintergrund

    SasG (Surface protein G) promotes adhesion of bacterial cells to human squamous nasal epithelial cells, a phenomenon which is likely to be important in nasal colonization. Forms short, extremely dense and thin fibrils all over the bacterial surface. SasG (Surface protein G) does not bind to either buccal cells or non-differentiated keratinocytes. SasG (Surface protein G) promotes cellular aggregation leading to biofilm formation. SasG (Surface protein G) is secreted, cell wall protein. It is produced during infection of the human host. SasG (Surface protein G) does not bind to immobilized fibrinogen, fibronectin, IgG, human epidermal keratin, collagen, vWF, laminin, heparan sulfate and submaxillary mucin. When sasG is expressed at high levels, it inhibits adhesion of S.aureus to the ligands fibrinogen, fibronectin, cytokeratin 10 and IgG. This inhibitory effect depends on the number of G5 repeats present in the protein, since shorter variants do not present this phenotype. Biofilm formation is ica-independent, relying only on the level of expression of the protein and the number of G5 repeats.
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