Influenza A Matrix Protein 2 Antikörper (Influenza A Virus) (N-Term)

Produktnummer ABIN966508

Produktdetails

Target: Influenza A Matrix Protein 2 (M2)

Bindungsspezifität: N-Term

Reaktivität: Influenza A Virus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC)

Aufreinigung: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of influenza A virus Matrix protein M2

Anwendungsinformationen

Applikationshinweise: ELISA, Western blotting: 1µg/ml for 2hrs.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Antigendetails

Target: Influenza A Matrix Protein 2 (M2)

Abstract: M2 Produkte

Synonyme: matrix protein 2 antikoerper

Substanzklasse: Influenza Protein

Hintergrund: The Matrix protein M2 forms a protons channel. When the environmental pH is lower than a threshold, the M2 channel is activated and selectively transports protons accross the membrane from the extracellular side to the cytoplasmic side. It is crucial for the uncoating process. When the virion is internalized into the endosome the channel can acidify the virion interior, promoting the dissociation of the viral matrix protein (M1) from the ribonucleoprotein (RNP) thus allowing the transport of the RNP from the virion into the cell's nucleus. For some influenza virus subtypes, the M2 channel can elevate the intravesicular pH of the trans-Golgi network, preventing the viral protein haemagglutinin, which is transported to the cell surface through the trans-Golgi network, from incorrect maturation in an otherwise low pH environment