LCK Antikörper

Produktnummer ABIN966480

Zitiert in 3+ Publikationen. Der Monoklonal anti-LCK Antikörper (ABIN966480) detektiert spezifisch LCK in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für LCK Antikörper (ABIN966480)

Target: LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Monoklonal

Konjugat: Dieser LCK Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-LCK Antikörper

Spezifität: Ni-NTA purified truncated recombinant Lck expressed in E. Coli strain BL21 (DE3)

Aufreinigung: Crude ascites.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -20 °C

Referenzen für anti-LCK Antikörper (ABIN966480)

Mingjian, Wheeler, Cheng, Yonghai, Chen, Fitzwarryne, Wang: "HIV/AIDS prevalence and behaviour in drug users and pregnant women in Kashgar Prefecture: case report." in: Harm reduction journal, Vol. 3, pp. 7, (2006) (PubMed).

Stachlewitz, Hart, Bettencourt, Kebede, Schwartz, Ratnofsky, Calderwood, Waegell, Hirst: "A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection." in: The Journal of pharmacology and experimental therapeutics, Vol. 315, Issue 1, pp. 36-41, (2005) (PubMed).

Hawash, Kesavan, Magee, Geahlen, Harrison: "The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5683-91, (2002) (PubMed).

Details zu LCK

Target: LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))

Andere Bezeichnung: Lck

Hintergrund: Lck(lymphocyte-specific protein tyrosine kinase), with 509-amino acid protein (about 56kDa), belongs to the Src non-receptor tyrosine kinases family. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Lck is expressed predominantly in T cells and is localized to the inner surface of the plasma membrane. Lck is activated after T cell stimulation and is required for T-cell proliferation and IL-2 production. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. In addition, inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection.

Gen-ID: 3932

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling