Laminin beta 1 Antikörper (AA 31-270)

Produktnummer ABIN966474

Dieses Anti-Laminin beta 1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Laminin beta 1 in WB, IHC und ELISA. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für Laminin beta 1 Antikörper (AA 31-270) (ABIN966474)

Target: Laminin beta 1 (LAMB1) (Laminin, beta 1 (LAMB1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Laminin beta 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Klon: 2D9G5

Produktdetails anti-Laminin beta 1 Antikörper

Bindungsspezifität: AA 31-270

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of LAMB1 (aa31-270) expressed in E. Coli.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-Laminin beta 1 Antikörper (ABIN966474)

Virtanen, Korhonen, Petäjäniemi, Karhunen, Thornell, Sorokin, Konttinen: "Laminin isoforms in fetal and adult human adrenal cortex." in: The Journal of clinical endocrinology and metabolism, Vol. 88, Issue 10, pp. 4960-6, (2003) (PubMed).

Details zu Laminin beta 1

Target: Laminin beta 1 (LAMB1) (Laminin, beta 1 (LAMB1))

Andere Bezeichnung: LAMB1

Hintergrund: LAMB1: laminin, beta 1. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.
Synonyms: CLM, MGC142015

Gen-ID: 3912