IRS1 Antikörper

Produktnummer ABIN966417

Zitiert in 4+ Publikationen. Der Kaninchen Polyklonal anti-IRS1 Antikörper (ABIN966417) detektiert spezifisch IRS1 in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für IRS1 Antikörper (ABIN966417)

Target: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRS1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-IRS1 Antikörper

Spezifität: IRS-1 (Ab-307) antibody detects endogenous levels of total IRS-1 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human IRS-1 around the phosphorylation site of serine 307.

Anwendungsinformationen

Applikationshinweise: IHC: 1:50-1:100.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-IRS1 Antikörper (ABIN966417)

Tuncman, Hirosumi, Solinas, Chang, Karin, Hotamisligil: "Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 28, pp. 10741-6, (2006) (PubMed).

Shoelson, Lee, Goldfine: "Inflammation and insulin resistance." in: The Journal of clinical investigation, Vol. 116, Issue 7, pp. 1793-801, (2006) (PubMed).

Steppan, Wang, Whiteman, Birnbaum, Lazar: "Activation of SOCS-3 by resistin." in: Molecular and cellular biology, Vol. 25, Issue 4, pp. 1569-75, (2005) (PubMed).

Frolov, Drozdova, Kazanskaia, Ramdavon: "[The synchronization and desynchronization of the" in: Biulleten' eksperimental'noĭ biologii i meditsiny, Vol. 116, Issue 7, pp. 17-9, (1993) (PubMed).

Details zu IRS1

Target: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Andere Bezeichnung: IRS-1

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process