GSTP1 Antikörper

Produktnummer ABIN966240

Dieses Anti-GSTP1-Antikörper ist ein Monoklonal-Antikörper zur Detektion von GSTP1 in WB, IHC und ELISA. Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für GSTP1 Antikörper (ABIN966240)

Target: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Monoklonal

Konjugat: Dieser GSTP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-GSTP1 Antikörper

Spezifität: Ni-NTA purified truncated recombinant GSTP1 expressed in E. Coli strain BL21 (DE3)

Aufreinigung: Antibodies are purified by protein A affinity chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
IHC(F): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Referenzen für anti-GSTP1 Antikörper (ABIN966240)

Lin, Nelson: "Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells." in: Cancer research, Vol. 63, Issue 2, pp. 498-504, (2003) (PubMed).

Satoh, Itoh, Yamamoto, Tanaka, Hayakari, Ookawa, Yamazaki, Sato, Tsuchida, Hatayama: "Nrf2 transactivator-independent GSTP1-1 expression in "GSTP1-1 positive" single cells inducible in female mouse liver by DEN: a preneoplastic character of possible initiated cells." in: Carcinogenesis, Vol. 23, Issue 3, pp. 457-62, (2002) (PubMed).

Details zu GSTP1

Target: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Andere Bezeichnung: GSTP1

Hintergrund: GSTP1 (glutathione-S-transferase, pi 1), also called GST3/DFN7, which is located on chromosome 11q13 , is a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. GSTP1 act like a tumor suppressor gene, which when inactivated leads to tumor growth, and the -class glutathione S-transferase is commonly inactivated by somatic CpGisland hypermethylation in cancers of the prostate, liver, and breast. Methylation of regulatory sequences at the GSTP1 gene locus is found in the vast majority (>90%) of prostate carcinomas and is associated with transcriptional down-regulation.

Gen-ID: 2950

Pathways: Cellular Response to Molecule of Bacterial Origin