GRB7 Antikörper (C-Term)

Produktnummer ABIN966220

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch GRB7 in IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für GRB7 Antikörper (C-Term) (ABIN966220)

Target: GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRB7 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-GRB7 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human Growth factor receptor-bound protein 7 (GRB7 adapter protein) or Epidermal growth factor receptor GRB-7 (B47).

Anwendungsinformationen

Applikationshinweise: ELISA, Western blotting: 1µg/ml for 2hrs.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu GRB7

Target: GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))

Andere Bezeichnung: GRB7 (Growth factor receptor-bound protein 7)

Hintergrund: GRB7(Growth factor receptor-bound protein 7) is a potential signal transduction molecule, and a variant of human Grb7 which is associated with invasive esophageal carcinoma. GRB7 interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. GRB7 also binds to ERBB2 and interacts with RND1. GRB7 belongs to the GRB7/10/14 family and contains 1 PH domain, 1 Ras-associating domain and 1 SH2 domain.

Pathways: EGFR Signaling Pathway, Ribonucleoprotein Complex Subunit Organization