GPC1 Antikörper (C-Term)

Produktnummer ABIN966218

Der Kaninchen Polyklonal Anti-GPC1-Antikörper wurde für IHC validiert. Er ist geeignet, GPC1 in Proben von Human und Maus zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für GPC1 Antikörper (C-Term) (ABIN966218)

Target: GPC1 (Glypican 1 (GPC1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPC1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-GPC1 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human GPC1(Glypican-1 precursor)

Anwendungsinformationen

Applikationshinweise: ELISA, Western blotting: 1µg/ml for 2hrs.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-GPC1 Antikörper (ABIN966218)

Davies, Blackhall, Shanks, David, McGown, Swindell, Slade, Martin-Hirsch, Gallagher, Jayson: "Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 15, pp. 5178-86, (2004) (PubMed).

Details zu GPC1

Target: GPC1 (Glypican 1 (GPC1))

Andere Bezeichnung: GPC1

Hintergrund: GPC1(Glypican-1) is a cell surface proteoglycan that bears heparan sulfate. The protein is attached to the membrane by a GPI-anchor. This cell-associated glypican is further processed to give rise to a medium-released species. The glypican-1 is required for efficient TGF-beta1 signaling in pancreatic cancer cells. The syndecan-1 and glypican-1 have roles in progression of ovarian cancer. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation