FER Antikörper

Produktnummer ABIN966133

Dieser Maus Monoklonal Antikörper detektiert spezifisch FER in WB, ELISA, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human und Maus. Es wurde in 3+ Publikationen zitiert.

Kurzübersicht für FER Antikörper (ABIN966133)

Target: FER (FER Tyrosine Kinase (FER))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FER Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Klon: 5D2C4

Produktdetails anti-FER Antikörper

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human FER expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-FER Antikörper (ABIN966133)

Li, Cheng, Ling: "Isolation and characterization of Fe(III)-chelate reductase gene LeFRO1 in tomato." in: Plant molecular biology, Vol. 54, Issue 1, pp. 125-36, (2004) (PubMed).

Girault, Greengard: "The neurobiology of dopamine signaling." in: Archives of neurology, Vol. 61, Issue 5, pp. 641-4, (2004) (PubMed).

Fan, Di Ciano-Oliveira, Weed, Craig, Greer, Rotstein, Kapus: "Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase." in: The Biochemical journal, Vol. 380, Issue Pt 2, pp. 581-91, (2004) (PubMed).

Details zu FER

Target: FER (FER Tyrosine Kinase (FER))

Andere Bezeichnung: FER

Hintergrund: FER (fer tyrosine kinase) is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases, which shares a functional domain and is involved in signaling pathways through receptor tyrosine kinases (RTK) and cytokine receptors. The Fes /Fps family is distinct from c-Src, c-Abl and related nRTKs and was originally distinguished as a homolog to retroviral oncoproteins. In vivo, Fer kinase assembles into homotrimers via conserved coiled-coil domains. The N-terminal coiled-coil domains of Fer can autophosphorylate in trans, thereby regulating their cellular function through differential phosphorylation states. Growth factor exposure can induce tyrosine phosphorylation of Fer and recruitment of Fer to RTK complexes containing p85. It is expressed predominantly in mature hematopoietic cells of the granulocytic and monocytic lineage, and has been shown to be expressed in vascular endothelial cells. Fer is implicated in insulin signaling, cell-cell signaling, human prostatic proliferative diseases, and is involved in the regulation of G1 progression.
Synonyms: TYK3, FER

Molekulargewicht: 95kDa

Gen-ID: 2241