Estrogen Receptor alpha Antikörper
Kurzübersicht für Estrogen Receptor alpha Antikörper (ABIN966080)
Target
Alle Estrogen Receptor alpha (ESR1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Aufreinigung
- Crude ascites.
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Immunogen
- Ni-NTA purified truncated recombinant ER expressed in E. Coli strain BL21 (DE3)
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Isotyp
- IgG2b
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anti-Estrogen Receptor 1 (ESR1) (AA 246-273) antibody
ESR1 Reaktivität: Human, Maus WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB33807 unconjugated
anti-Estrogen Receptor 1 (ESR1) antibodyESR1 Reaktivität: Human WB, IHC, StM Wirt: Maus Monoclonal ESR1-1904 unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 129-312) antibodyESR1 Reaktivität: Human IHC, IF, FACS, StM Wirt: Maus Monoclonal ESR1-3557 unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 2-185) antibodyESR1 Reaktivität: Human, Ratte WB, IHC, ELISA, FACS, ICC Wirt: Maus Monoclonal 6A6E8 unconjugated
anti-Estrogen Receptor 1 (ESR1) (pSer167) antibodyESR1 Reaktivität: Human, Ratte ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 2-185) antibodyESR1 Reaktivität: Human WB, IHC, FACS, StM Wirt: Maus Monoclonal ER506 unconjugated
anti-Estrogen Receptor 1 (ESR1) (C-Term) antibodyESR1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 246-273) antibodyESR1 Reaktivität: Human WB, IHC, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 233-483) antibodyESR1 Reaktivität: Maus WB, IHC, ICC, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Estrogen Receptor 1 (ESR1) (AA 331-360) antibodyESR1 Reaktivität: Human, Ratte WB, ELISA, FACS, IF (cc) Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
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Western Blot: 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Lagerung
- -20 °C
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- Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
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Andere Bezeichnung
- Estrogen Receptor 1
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Hintergrund
- ER (estrogen receptor 1) a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD).Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ER regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ER activity. ER is phosphorylated on multiple sites. Serines 104, 106, 118 and 167 are located in the amino-terminal transcription activation function domain AF-1, and phosphorylation of these serines plays an important role in regulating ER activity. Ser118 may be the substrate of the transcription regulatory kinase cdK7. Ser167 may be phosphorylated by p90RSK and Akt. Phosphorylation of Ser167 may confer tamoxifen resistance in breast cancer patients.
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Pathways
- Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
Target
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