MUC1 Antikörper (DTRP (Asp-Thr-Arg-Pro))

Produktnummer ABIN966067

Dieses Maus Monoklonal-Antikörper erkennt spezifisch MUC1 in IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für MUC1 Antikörper (DTRP (Asp-Thr-Arg-Pro)) (ABIN966067)

Target: MUC1 (Mucin 1 (MUC1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MUC1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: B24-1 (GP1-4)

Produktdetails anti-MUC1 Antikörper

Bindungsspezifität: DTRP (Asp-Thr-Arg-Pro)

Aufreinigung: Concentrated.

Immunogen: Human Milk Fat Globule Membranes

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry: (Paraffin/Frozen): 1:50.
Staining Procedure: Prolonged fixation in buffered formalin can destroy the epitope. The antibody may be used at a dilution of 1:50 in IHC. It is recommended that this product be used on frozen tissue sections or specimens. The optimal conditions should be determined by the individual laboratory.

Kommentare:

Cellular Localization: Cell Membrane, Cytoplasmic.
Recommended Positive Control: Breast Carcinoma

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.3 mg/ml.

Buffer: 20 mM Tris-Borate, 150 mM Sodium Chloride, dialyzed media RPMI 1640/D-MEM containing Fetal Bovine Serum, BMC-6 Carrier Polysaccharides, Carrier Protein, pH 7.5

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-MUC1 Antikörper (ABIN966067)

Hilkens, Ligtenberg, Vos, Litvinov: "Cell membrane-associated mucins and their adhesion-modulating property." in: Trends in biochemical sciences, Vol. 17, Issue 9, pp. 359-63, (1992) (PubMed).

Hilkens, Buijs, Hilgers, Hageman, Calafat, Sonnenberg, van der Valk: "Monoclonal antibodies against human milk-fat globule membranes detecting differentiation antigens of the mammary gland and its tumors." in: International journal of cancer. Journal international du cancer, Vol. 34, Issue 2, pp. 197-206, (1984) (PubMed).

Details zu MUC1

Target: MUC1 (Mucin 1 (MUC1))

Andere Bezeichnung: EMA

Hintergrund: Reacts with human high molecular weight sialomucin, episialin, mucin 1 (MUC-1), or polymorphic epithelial mucin (PEM). It recognizes the multiple protein epitope that is relatively insensitive to glycosylation. Therefore, it is very sensitive in the detection of episialin expression in different epithelial tissues.

Molekulargewicht: 265-400 kDa

Gen-ID: 4582

Pathways: Negative Regulation of intrinsic apoptotic Signaling