Dynamin 1 Antikörper

Produktnummer ABIN966017

Der Monoklonal Anti-Dynamin 1-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, Dynamin 1 in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für Dynamin 1 Antikörper (ABIN966017)

Target: Dynamin 1 (DNM1)

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Monoklonal

Konjugat: Dieser Dynamin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-Dynamin 1 Antikörper

Spezifität: Ni-NTA purified truncated recombinant Dynamin-1 expressed in E. Coli strain BL21 (DE3)

Aufreinigung: Crude ascites.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
IHC(F): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000 Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -20 °C

Referenzen für anti-Dynamin 1 Antikörper (ABIN966017)

Yoo, Jeong, Kwon, Hur, Park, Han: "Activation of dynamin I gene expression by Sp1 and Sp3 is required for neuronal differentiation of N1E-115 cells." in: The Journal of biological chemistry, Vol. 277, Issue 14, pp. 11904-9, (2002) (PubMed).

Details zu Dynamin 1

Target: Dynamin 1 (DNM1)

Andere Bezeichnung: Dynamin-1

Hintergrund: Dynamin-1 (Dyn1), with 864-amino acid protein (about 95kDa), belongs to the dynamin family. Dynamin-1 (neuron-specific), dynamin-2 (ubiquitously expressed), and dynamin-3 (expressed only in the testis, brain, and lung), constitute the dynamin family. Members of the dynamin family are GPTase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin-1 is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C. Dynamin-1 is a large GTPase enzyme required in membrane constriction and fission during multiple forms of endocytosis. Dynamin-1 is also a key molecule required for the recycling of synaptic vesicles in neurons, and it has been known that dynamin-1 gene expression is induced during neuronal differentiation.

Pathways: Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling