DNAJA3 Antikörper (C-Term)

Produktnummer ABIN966005

Der Kaninchen-Polyklonal Anti-DNAJA3-Antikörper wurde für IHC validiert. Er ist geeignet zum Nachweis von DNAJA3 in Proben aus Human und Maus. }

Kurzübersicht für DNAJA3 Antikörper (C-Term) (ABIN966005)

Target: DNAJA3 (DnaJ (Hsp40) Homolog, Subfamily A, Member 3 (DNAJA3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNAJA3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-DNAJA3 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of mouse DnaJa3 (DnaJ homolog subfamily A member 3, mitochondrial precursor)

Anwendungsinformationen

Applikationshinweise: ELISA, Western blotting: 1µg/ml for 2hrs.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu DNAJA3

Target: DNAJA3 (DnaJ (Hsp40) Homolog, Subfamily A, Member 3 (DNAJA3))

Andere Bezeichnung: DnaJa3

Hintergrund: DnaJa3(DnaJ homolog subfamily A member 3) modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. DnaJa3 affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C, in sharp contrast, isoform 2 suppresses apoptosis. DnaJa3 can modulate IFN-gamma-mediated transcriptional activity. It interacts with JAK2, HSPA9B and IFN-gammaR2 chain. It also interacts with Ras GTPase-activating protein 1 (RASA1). Modulation of apoptosis, i.e proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J domaindependent. DnaJa3 contains 1 CR domain and 1 J domain.

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity