Desmin Antikörper

Produktnummer ABIN965993

Der Monoklonal Anti-Desmin-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, Desmin in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für Desmin Antikörper (ABIN965993)

Target: Desmin (DES)

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Monoklonal

Konjugat: Dieser Desmin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-Desmin Antikörper

Spezifität: Ni-NTA purified truncated recombinant Desmin expressed in E. Coli strain BL21 (DE3)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 1,000- 1: 2,000
IHC(P): 1: 1,000- 1: 2,000
IHC(F): 1: 1,000- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Referenzen für anti-Desmin Antikörper (ABIN965993)

Shardonofsky, Capetanaki, Boriek: "Desmin modulates lung elastic recoil and airway responsiveness." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 290, Issue 5, pp. L890-6, (2006) (PubMed).

Huang, Li, Foster, Lemanski, Dube, Zhang, Lemanski: "Protein kinase C-mediated desmin phosphorylation is related to myofibril disarray in cardiomyopathic hamster heart." in: Experimental biology and medicine (Maywood, N.J.), Vol. 227, Issue 11, pp. 1039-46, (2002) (PubMed).

Details zu Desmin

Target: Desmin (DES)

Andere Bezeichnung: Desmin

Hintergrund: Desmin (DES), with 470-amino acid protein (about 52kDa), belongs to the intermediate filament family and Desmin is class III intermediate filaments found in muscle cells. Homopolymers of Desmin form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane.Mutations in Desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.Desmin is also expressed in smooth muscle cells of both airways and alveolar ducts and Desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response.

Gen-ID: 1674