DAXX Antikörper

Produktnummer ABIN965974

Dieses Maus Monoklonal-Antikörper erkennt spezifisch DAXX in WB, ELISA, IF und FACS. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für DAXX Antikörper (ABIN965974)

Target: DAXX (Death-Domain Associated Protein (DAXX))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DAXX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: 7A11

Produktdetails anti-DAXX Antikörper

Aufreinigung: Antibody are purified by protein G affinity chromatography.

Immunogen: Purified recombinant fragment of human DAXX expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-DAXX Antikörper (ABIN965974)

Ryu, Chae, Kim: "Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9." in: Biochemical and biophysical research communications, Vol. 279, Issue 1, pp. 6-10, (2000) (PubMed).

Yang, Khosravi-Far, Chang, Baltimore: "Daxx, a novel Fas-binding protein that activates JNK and apoptosis." in: Cell, Vol. 89, Issue 7, pp. 1067-76, (1997) (PubMed).

Details zu DAXX

Target: DAXX (Death-Domain Associated Protein (DAXX))

Andere Bezeichnung: DAXX

Hintergrund: DAXX (death-domain associated protein), it is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
Synonyms: DAP6, EAP1, BING2

Molekulargewicht: 81kDa

Gen-ID: 1616

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway