CLOCK Antikörper (N-Term)

Produktnummer ABIN965906

Der Kaninchen Polyklonal Anti-CLOCK-Antikörper wurde für IHC validiert. Er ist geeignet, CLOCK in Proben von Human und Maus zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für CLOCK Antikörper (N-Term) (ABIN965906)

Target: CLOCK (Clock Homolog (Mouse) (CLOCK))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLOCK Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-CLOCK Antikörper

Bindungsspezifität: N-Term

Aufreinigung: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human CLOCK(Circadian locomoter output cycles protein kaput)

Anwendungsinformationen

Applikationshinweise: ELISA, Western blotting: 1µg/ml for 2hrs.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-CLOCK Antikörper (ABIN965906)

Moreira, Pedrazzoli, Dos Santos Coelho, Pradella-Hallinan, Lopes da Conceição, Pereira Peregrino, de Oliveira, Tufik: "Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients." in: Brain research. Molecular brain research, Vol. 140, Issue 1-2, pp. 150-4, (2005) (PubMed).

Details zu CLOCK

Target: CLOCK (Clock Homolog (Mouse) (CLOCK))

Andere Bezeichnung: CLOCK

Hintergrund: CLOCK(Circadian locomoter output cycles protein kaput) is a circadian regulator that acts as a transcription factor. CLOCK-BMAL1 heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Mutant CLOCK and BMAL1 form hetereodimers that bind DNA, but fail to activate transcription. CLOCK belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.

Pathways: Regulation of Lipid Metabolism by PPARalpha, Photoperiodism