KRT17 Antikörper

Produktnummer ABIN965900

Produktdetails anti-KRT17 Antikörper

Target: KRT17 (Keratin 17 (KRT17))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KRT17 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of CK17 expressed in E. Coli.

Klon: 3B12

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-KRT17 Antikörper (ABIN965900)

van de Rijn, Perou, Tibshirani, Haas, Kallioniemi, Kononen, Torhorst, Sauter, Zuber, Köchli, Mross, Dieterich, Seitz, Ross, Botstein, Brown: "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome." in: The American journal of pathology, Vol. 161, Issue 6, pp. 1991-6, (2002) (PubMed).

Leigh, Navsaria, Purkis, McKay, Bowden, Riddle: "Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro." in: The British journal of dermatology, Vol. 133, Issue 4, pp. 501-11, (1995) (PubMed).

Details zu KRT17

Target: KRT17 (Keratin 17 (KRT17))

Andere Bezeichnung: CK17 (KRT17 Produkte)

Synonyme: K17 antikoerper, Krt1-17 antikoerper, PC antikoerper, PC2 antikoerper, PCHC1 antikoerper, Ka17 antikoerper, KRT17 antikoerper, krt16 antikoerper, si:dkeyp-113d7.7 antikoerper, KRT14 antikoerper, keratin 17 antikoerper, keratin 17 L homeolog antikoerper, keratin 17, type I antikoerper, keratin, type I cytoskeletal 17 antikoerper, Krt17 antikoerper, KRT17 antikoerper, krt17 antikoerper, krt17.L antikoerper, LOC100737113 antikoerper, LOC102177275 antikoerper

Hintergrund: CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
Synonyms: PC, K17, PC2, PCHC1, KRT17

Molekulargewicht: 49kDa

Gen-ID: 3872