CD20 Antikörper

Produktnummer ABIN965776

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD20 in IHC, IF und ELISA. Er zeigt eine Reaktivität gegenüber Human und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für CD20 Antikörper (ABIN965776)

Target: CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD20 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA

Klon: 3E9D3C1G3

Produktdetails anti-CD20 Antikörper

Aufreinigung: Ascitic fluid

Immunogen: Synthetic peptide corresponding to aa (EPANPSEKNSPSTQY) of human CD20,conjugated to KLH.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-CD20 Antikörper (ABIN965776)

Riley, Byar: "The rationale for and background of radioimmunotherapy: an emerging therapy for B-cell non-Hodgkin's lymphoma." in: Seminars in oncology nursing, Vol. 20, Issue 1 Suppl 1, pp. 1-7, (2004) (PubMed).

Reiners, Hansen, Krüssmann, Schön, Csernok, Gross, Engert, Von Strandmann: "Selective killing of B-cell hybridomas targeting proteinase 3, Wegener's autoantigen." in: Immunology, Vol. 112, Issue 2, pp. 228-36, (2004) (PubMed).

Byar: "Educating patients about radioimmunotherapy with yttrium 90 ibritumomab tiuxetan (Zevalin)." in: Seminars in oncology nursing, Vol. 20, Issue 1 Suppl 1, pp. 20-5, (2004) (PubMed).

Details zu CD20

Target: CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))

Andere Bezeichnung: CD20

Hintergrund: CD20 (MS4A1, membrane-spanning 4-domains, subfamily A, member 1) is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The CD20 antigen is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells. Low level expression of the CD20 antigen has been detected on normal T lymphocytes. The CD20 molecule is involved in regulation of B cell differentiation, presumably via its reported function as a Ca++ channel subunit. And it is known to accelerate the G0 to G1 progression induced by IGF-1.
Synonyms: B1, S7, Bp35, CD20, MS4A2, LEU-16, MGC3969, MS4A1

Gen-ID: 931