Ataxin 10 Antikörper (C-Term)

Produktnummer ABIN965623

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Ataxin 10 in IHC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für Ataxin 10 Antikörper (C-Term) (ABIN965623)

Target: Ataxin 10 (ATXN10)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ataxin 10 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-Ataxin 10 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ATXN10(Ataxin-10)

Anwendungsinformationen

Applikationshinweise: ELISA, Western blotting: 1µg/ml for 2hrs.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-Ataxin 10 Antikörper (ABIN965623)

Matsuura, Fang, Pearson, Jayakar, Ashizawa, Roa, Nelson: "Interruptions in the expanded ATTCT repeat of spinocerebellar ataxia type 10: repeat purity as a disease modifier?" in: American journal of human genetics, Vol. 78, Issue 1, pp. 125-9, (2005) (PubMed).

Wiemann, Weil, Wellenreuther, Gassenhuber, Glassl, Ansorge, Böcher, Blöcker, Bauersachs, Blum, Lauber, Düsterhöft, Beyer, Köhrer, Strack, Mewes, Ottenwälder, Obermaier, Tampe, Heubner, Wambutt, Korn et al.: "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. ..." in: Genome research, Vol. 11, Issue 3, pp. 422-35, (2001) (PubMed).

Matsuura, Yamagata, Burgess, Rasmussen, Grewal, Watase, Khajavi, McCall, Davis, Zu, Achari, Pulst, Alonso, Noebels, Nelson, Zoghbi, Ashizawa: "Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10." in: Nature genetics, Vol. 26, Issue 2, pp. 191-4, (2000) (PubMed).

Details zu Ataxin 10

Target: Ataxin 10 (ATXN10)

Andere Bezeichnung: ATXN10

Hintergrund: The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and a varying degree of signs from other components of the nervous system. Defects in ATXN10 are the cause of spinocerebellar ataxia type 10. SCA10 is an autosomal dominant disorder and is predominantly characterized by cerebellar ataxia seizures. In addition patients often show soft pyramidal signs, ocular dyskinesia, cognitive impairment, and/or behavioral disturbances. SCA10 has been recognized only in families of Mexican origin. The molecular basis of the disease is due to an ATTCT nucleotide repeat expansion in intron 9.