Thyroid Hormone Receptor, beta (THRB) (Isoform 1), (N-Term) Antikörper

Details zu Produkt Nr. ABIN964895
Antigen
  • C-ERBA-2
  • C-ERBA-BETA
  • ERBA2
  • GRTH
  • NR1A2
  • PRTH
  • THR1
  • THRB1
  • THRB2
  • Nr1a2
  • T3R[b]
  • T3Rbeta
  • Thrb1
  • Thrb2
  • c-erbAbeta
  • TR-beta
  • TR[b]1
  • fj24f03
  • trb
  • wu:fj24f03
  • CTR BETA 2
  • TR-BETA
  • LOC734147
  • thrb
  • THRB
  • C-erba-beta
  • RATT3REC
  • T3rec
  • TRbeta
  • THR
  • TRbeta1
  • thyroid hormone receptor beta
  • thyroid hormone receptor, beta
  • thyroid hormone receptor, beta S homeolog
  • THRB
  • Thrb
  • thrb
  • thrb.S
Epitop
N-Term, Isoform 1
23
20
6
5
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
115
64
64
19
10
8
7
6
5
4
4
3
1
1
1
Wirt
Kaninchen
96
34
9
Klonalität
Polyklonal
Konjugat
Unkonjugiert
5
4
4
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
102
67
37
13
9
7
6
6
3
3
2
1
1
1
Optionen
Immunogen This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the of human THRB protein.
Isotyp IgG
Kreuzreaktivität Maus, Ratte (Rattus)
Produktmerkmale Concentration Definition: by UV absorbance at 280 nm
Antigen
Andere Bezeichnung Thyroid Hormone Receptor beta 1 (THRB Antibody Abstract)
Hintergrund Anti-Thyroid Hormone Receptor ß1 (TRB1) antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). This TRB1 antibody is ideal for Immunology, Thyroid and Signal Tranduction research.
Synonyms: Thyroid hormone receptor beta TRB1 TR beta signaling c-erbA-beta c-erbA-2 Nuclear receptor subfamily 1 group A member 2
Gen-ID 7068, 40806162
UniProt P10828
Pathways Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound
Applikations-hinweise This affinity purified antibody has been tested for use in ELISA and western blotting.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1.0 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Bilder des Herstellers
 image for anti-Thyroid Hormone Receptor, beta (THRB) (Isoform 1), (N-Term) antibody (ABIN964895) anti-Thyroid Hormone Receptor, beta (THRB) (Isoform 1), (N-Term) antibody
Immunofluorescence (IF) image for anti-Thyroid Hormone Receptor, beta (THRB) (Isoform 1), (N-Term) antibody (ABIN964895) Immunofluorescence microscopy anti -THRB1 (Thyroid hormone receptor Beta 1) antibody ...
Produkt verwendet in: Fozzatti, Park, Zhao, Willingham, Cheng: "Oncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer." in: PLoS ONE, Vol. 8, Issue 6, pp. e67954, 2017 (PubMed).

Zhao, Zhu, Won Park, Fozzatti, Willingham, Cheng: "Role of TSH in the spontaneous development of asymmetrical thyroid carcinoma in mice with a targeted mutation in a single allele of the thyroid hormone-β receptor." in: Endocrinology, Vol. 153, Issue 10, pp. 5090-100, 2012 (PubMed).

Mascanfroni, Montesinos, Alamino, Susperreguy, Nicola, Ilarregui, Masini-Repiso, Rabinovich, Pellizas: "Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling." in: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 9569-82, 2010 (PubMed).

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