THRB Antikörper (Isoform 1, N-Term)

Produktnummer ABIN964895

Produktdetails anti-THRB Antikörper

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Bindungsspezifität: Isoform 1, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THRB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Maus, Ratte (Rattus)

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the of human THRB protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA and western blotting.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-THRB Antikörper (ABIN964895)

Fozzatti, Park, Zhao, Willingham, Cheng: "Oncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer." in: PLoS ONE, Vol. 8, Issue 6, pp. e67954, (2017) (PubMed).

Zhao, Zhu, Won Park, Fozzatti, Willingham, Cheng: "Role of TSH in the spontaneous development of asymmetrical thyroid carcinoma in mice with a targeted mutation in a single allele of the thyroid hormone-β receptor." in: Endocrinology, Vol. 153, Issue 10, pp. 5090-100, (2012) (PubMed).

Mascanfroni, Montesinos, Alamino, Susperreguy, Nicola, Ilarregui, Masini-Repiso, Rabinovich, Pellizas: "Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling." in: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 9569-82, (2010) (PubMed).

Details zu THRB

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Andere Bezeichnung: Thyroid Hormone Receptor beta 1 (THRB Produkte)

Synonyme: C-ERBA-2 antikoerper, C-ERBA-BETA antikoerper, ERBA2 antikoerper, GRTH antikoerper, NR1A2 antikoerper, PRTH antikoerper, THR1 antikoerper, THRB1 antikoerper, THRB2 antikoerper, Nr1a2 antikoerper, T3R[b] antikoerper, T3Rbeta antikoerper, Thrb1 antikoerper, Thrb2 antikoerper, c-erbAbeta antikoerper, TR-beta antikoerper, TR[b]1 antikoerper, fj24f03 antikoerper, trb antikoerper, wu:fj24f03 antikoerper, CTR BETA 2 antikoerper, TR-BETA antikoerper, LOC734147 antikoerper, thrb antikoerper, THRB antikoerper, C-erba-beta antikoerper, RATT3REC antikoerper, T3rec antikoerper, TRbeta antikoerper, THR antikoerper, TRbeta1 antikoerper, thyroid hormone receptor beta antikoerper, thyroid hormone receptor, beta antikoerper, thyroid hormone receptor, beta S homeolog antikoerper, thyroid hormone receptor, beta L homeolog antikoerper, THRB antikoerper, Thrb antikoerper, thrb antikoerper, thrb.S antikoerper, thrb.L antikoerper

Hintergrund: Anti-Thyroid Hormone Receptor ß1 (TRB1) antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). This TRB1 antibody is ideal for Immunology, Thyroid and Signal Tranduction research.
Synonyms: Thyroid hormone receptor beta TRB1 TR beta signaling c-erbA-beta c-erbA-2 Nuclear receptor subfamily 1 group A member 2

Gen-ID: 7068, 40806162

UniProt: P10828

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound