Involucrin Antikörper

Produktnummer ABIN960541

Produktdetails anti-Involucrin Antikörper

Target: Involucrin (IVL)

Reaktivität: Human, Schwein, Hund, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Involucrin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Marke: IHC-plus™

Spezifität: Recognizes human involucrin, a 585 amino acid soluble protein encoded by the IVL gene and expressed in epidermal keratinocytes as they tend towards terminal differentiation. Involucrin is produced in the stratum spinosum initially in the cell cytosol from where it moves to the cell membrane, associates with transglutaminase and becomes cross-linked to membrane proteins, offering structural support to the cell and forming a stable envelope below the plasma membrane. Recognizes an epitope between residues 421-568 of human involucrin. Involucrin expression is seen in the normal granular cells of the epidermis associated with the plasma membrane during the early phase of cornified envelope maturation and expression is increased in psoriatic epidermis with abnormal cornified envelope maturation. Involucrin staining is also maintained, associated with the cornified envelope in epidermolytic hyperkeratosis, a condition associated with mutations to mutations in genes coding for cytokeratins 1 and 10.

Keine Kreuzreaktivität: Maus

Aufreinigung: Protein A purified

Immunogen: Native, from keratinocytes.

Klon: SY5

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Approved: ELISA, IHC, IHC-Fr, IHC-P (10 μg/mL), IP, WB

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS, 0.09 % sodium azide. Sourced in TCS.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: avoid freeze thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.

Details zu Involucrin

Target: Involucrin (IVL)

Andere Bezeichnung: IVL / Involucrin (IVL Produkte)

Synonyme: INV antikoerper, NPH2 antikoerper, NPHP2 antikoerper, 1110019C06Rik antikoerper, IVL antikoerper, Nphp2 antikoerper, inv antikoerper, involucrin antikoerper, inversin antikoerper, IVL antikoerper, INVS antikoerper, Ivl antikoerper, Invs antikoerper

Hintergrund: Name/Gene ID: IVL

Synonyms: IVL, Involucrin

Gen-ID: 3713

UniProt: P07476