Melanoma Associated Antigen Antikörper

Produktnummer ABIN959527

Dieser Maus Monoklonal Antikörper erkennt spezifisch Melanoma Associated Antigen in IHC, ELISA, IHC (fro), IF, IHC (p) und IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Melanoma Associated Antigen Antikörper (ABIN959527)

Target: Melanoma Associated Antigen (MAGE)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Melanoma Associated Antigen Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Klon: NKI-C3

Produktdetails anti-Melanoma Associated Antigen Antikörper

Spezifität: Used for diagnostic by staining of lysosomes/melanosomes. Directed against a predominantly intracellular protein of human melanoma cells. The antigen is abundantly present in malignant melanomas, nevocellular nevi, and neuroendocrine tumors, whereas it has not been detectable in most other tissues. The antigen recognized is a glycoprotein which appears as a broad band in SDS-PAGE. The antigen was shown to consist of a single protein backbone to which two or three V-linked glycans were added cotranslationally. Extensive further heterogeneity was generated in the Colgi compartmen and was shown to be dependent on the presence of complex type sugars. Although the antigen is associated with melanomas, it was not codistributed with the tyrosinase activity associated with melanogenesis. The antigen did show codistribution with cathepsin D, which is a marker for lysosomal functions.This antibody was originally described as a marker for melanoma. Recently, it resurfaced as a marker to separate cellular neurothekeoma from other dermal tumors in the differential diagnosis.

Aufreinigung: Purified

Immunogen: Melanoma-associated antigen

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Approved: ELISA, IF, IHC, IHC-Fr, IHC-P (10 μg/mL), IP

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: avoid freeze thaw cycles. Store undiluted.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles. Store undiluted.

Details zu Melanoma Associated Antigen

Target: Melanoma Associated Antigen (MAGE)

Andere Bezeichnung: Melanoma-Associated Antigen