Uromodulin Antikörper (HRP)

Produktnummer ABIN955476

Dieses Anti-Uromodulin-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Uromodulin in IHC (p), IF, IHC (fro), EIA und RIA. Geeignet für Human und Hund.

Kurzübersicht für Uromodulin Antikörper (HRP) (ABIN955476)

Target: Uromodulin (UMOD)

Reaktivität: Human, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Uromodulin Antikörper ist konjugiert mit HRP

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Radioimmunoassay (RIA)

Klon: 01-10-32

Produktdetails anti-Uromodulin Antikörper (HRP)

Spezifität: Anti-Human Tamm-Horsfall protein (THP) is a monoclonal antibody which reacts with an epitope of the urinary mucoprotein. This monoclonal antibody has shown good localization to the distal tubule and collecting duct as well as to large deposits of Tamm-Horsfall protein which has clogged peri-pelvic veins. This antibody has been tested against 21 different Human proteins in Solid Phase Radioimmunoassay and has been shown to be specific for Tamm-Horsfall protein only. Results of ELISA show no visible reaction with Human albumin or transferrin. Also no staining of Human tissue other than that noted for kidney sections has been observed.

Kreuzreaktivität (Details): Species reactivity (expected):Canine (Dog).
Species reactivity (tested):Human.

Aufreinigung: Protein G Chromatography.

Immunogen: Human Tamm-Horsfall protein.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS containing 50 % Glycerol (v/v)., 4-5 mg/mL BSA

Vorsichtsmaßnahmen: Avoid exposure of conjugate to Sodium Azide or Thimerosal, as these can inhibit peroxidase activity.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted at (in aliquots) at -20 °C. This product is photosensitive and should be protected from light.

Details zu Uromodulin

Target: Uromodulin (UMOD)

Hintergrund: Tamm-Horsfall Protein (THP) is a glycoprotein of approximately 80 kDa containing up to 25 % carbohydrate by weight. It exists as a high molecular weight polymer in urine and approximately 50 mg of the THP are excreted per day by adult humans. THP is produced by the epithelial cells lining the thick ascending loop of Henle and distal convoluted tubules of the kidney. THP is also the primary constituent of renal tubular casts and THP aggregation has been implicated as a factor in the pathogenesis of acute renal failure by causing tubular obstruction. Antibody to THP is present in the serum of patients with pyelonephritis and reflus uropathy.Synonyms: THP, Tamm-Horsfall urinary glycoprotein

Gen-ID: 7369

NCBI Accession: NP_001008390

UniProt: P07911