Transferrin Receptor 2 Antikörper (C-Term)

Produktnummer ABIN955173

Dieses Anti-Transferrin Receptor 2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Transferrin Receptor 2 in WB und EIA. Geeignet für Human.

Kurzübersicht für Transferrin Receptor 2 Antikörper (C-Term) (ABIN955173)

Target: Transferrin Receptor 2 (TFR2)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Transferrin Receptor 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-Transferrin Receptor 2 Antikörper

Bindungsspezifität: AA 673-703, C-Term

Spezifität: This antibody detects Human TFR2 (C-term). Other species not tested.

Aufreinigung: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 673-703 amino acids from the C-terminal region of human TFR2

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Details zu Transferrin Receptor 2

Target: Transferrin Receptor 2 (TFR2)

Andere Bezeichnung: TFR2

Hintergrund: This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. Function: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Cellular Location: Cell membrane, Single-pass type II membrane protein. Tissue Location: Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly.Synonyms: Transferrin receptor protein 2

Molekulargewicht: 88755 Da (Calculated)

Gen-ID: 7036

NCBI Accession: NP_001193784

Pathways: Transition Metal Ion Homeostasis