Importin 11 Antikörper (C-Term)

Produktnummer ABIN954448

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Importin 11 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Importin 11 Antikörper (C-Term) (ABIN954448)

Target: Importin 11 (IPO11)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Importin 11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-Importin 11 Antikörper

Bindungsspezifität: AA 906-970, C-Term

Spezifität: This antibody recognizes Human RanBP11 / Importin-11 (C-term).

Aufreinigung: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 906~970 amino acids from the C-terminal region of Human RanBP11 / Importin-11 Genename: IPO11

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Importin 11

Target: Importin 11 (IPO11)

Andere Bezeichnung: RanBP11 / Importin-11

Hintergrund: IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). It mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).Synonyms: IPO11, Imp11, Ran-binding protein 11

Molekulargewicht: 112535 Da

Gen-ID: 51194

NCBI Accession: NP_001128251

Pathways: Protein targeting to Nucleus