PNN Antikörper (Middle Region)

Produktnummer ABIN954147

Der Kaninchen Polyklonal anti-PNN Antikörper (ABIN954147) detektiert spezifisch PNN in WB, IF, IHC (p) und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PNN Antikörper (Middle Region) (ABIN954147)

Target: PNN (Pinin, Desmosome Associated Protein (PNN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PNN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-PNN Antikörper

Bindungsspezifität: AA 216-248, Middle Region

Spezifität: This antibody recognizes Human Pinin / PNN (Center).

Aufreinigung: Affinitty Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 216-248 amino acids from the Central region of human PNN.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PNN

Target: PNN (Pinin, Desmosome Associated Protein (PNN))

Andere Bezeichnung: Pinin / PNN

Hintergrund: Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene, the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.Synonyms: 140 kDa nuclear and cell adhesion-related phosphoprotein, DRS, DRSP, Desmosome-associated protein, Domain-rich serine protein, MEMA, Nuclear protein SDK3

Molekulargewicht: 81614 Da

Gen-ID: 5411

NCBI Accession: NP_002678