MBP Antikörper

Produktnummer ABIN953563

Dieses Huhn Polyklonal-Antikörper erkennt spezifisch MBP in WB und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für MBP Antikörper (ABIN953563)

Target: MBP (Myelin Basic Protein (MBP))

Reaktivität: Human, Maus, Ratte

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser MBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-MBP Antikörper

Spezifität: Specific for the ~18k & 22k myelin basic protein in Western blots of Rat brain homogenate.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Bovine, Mouse and Rat.

Aufreinigung: Ig Fraction

Immunogen: Three peptide sequences conserved in higher vertebrate MBP proteins.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at -20 °C.

Details zu MBP

Target: MBP (Myelin Basic Protein (MBP))

Andere Bezeichnung: Myelin Basic Protein

Hintergrund: Myelin Basic Protein (MBP) is one of the major proteins of the myelin sheath surrounding axons in the nervous system. Since it is of relatively low molecular weight and high abundance the protein sequence was determined from purified protein over 30 years ago (Eylar et al., 1971). The protein is made by oligodendrocytes in the central nervous system, so antibodies to MBP are good markers of this cell type. However, transcripts from the same gene are also expressed in certain hematopoetic lineage cells (Marty et al., 2002). In the central nervous system there are there different forms of the protein made by alternate transcription from a single gene, which have molecular weights of 21.5, 18.5, and 17.2 kDa. Since the two lower molecular weight forms are very close in molecular size, MBP antibodies typically show two bands on Western blots, one at about 22 kDa and another at about 18 kDa.Synonyms: MBP, Myelin membrane encephalitogenic protein

Gen-ID: 4155

NCBI Accession: NP_001020252

UniProt: P02686