MRPS12 Antikörper (Middle Region)

Produktnummer ABIN953516

Der Kaninchen Polyklonal Anti-MRPS12-Antikörper wurde für WB, IHC (p) und EIA validiert. Er ist geeignet, MRPS12 in Proben von Human zu detektieren.

Kurzübersicht für MRPS12 Antikörper (Middle Region) (ABIN953516)

Target: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MRPS12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-MRPS12 Antikörper

Bindungsspezifität: AA 35-67, Middle Region

Spezifität: This antibody recognizes Human MRPS12 (Center).

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 35-67 amino acids from the Central region of Human MRPS12 Genename: MRPS12

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu MRPS12

Target: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Andere Bezeichnung: MRPS12

Hintergrund: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75 % protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene, all three variants encode the same proteinSynonyms: 28S ribosomal protein S12, MRP-S12, MT-RPS12, RPMS12, RPSM12, S12mt, mitochondrial

Gen-ID: 6183

NCBI Accession: NP_066930

Pathways: Sensory Perception of Sound