MHC Class I H-2KdDd Antikörper (Biotin)

Produktnummer ABIN953423

Der Maus Monoklonal anti-MHC Class I H-2KdDd Antikörper wird verwendet zum Nachweis von MHC Class I H-2KdDd in Proben von Maus. Er wurde validiert für FACS.

Kurzübersicht für MHC Class I H-2KdDd Antikörper (Biotin) (ABIN953423)

Target: MHC Class I H-2KdDd

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Biotin

Applikation: Flow Cytometry (FACS)

Klon: 34-1-2S

Produktdetails

Aufreinigung: Protein G Chromatography

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Antigendetails

Target: MHC Class I H-2KdDd

Andere Bezeichnung: MHC Class I H2 Kd/Dd

Hintergrund: The 'classical' MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant beta 2-Microglobulin. (Ref.3,4) These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. (Ref.5) MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny. (Ref.3,6)